(Q39667316)

13 September 2017

title

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition (English)

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13 September 2017

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5

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13 September 2017

Carmine Settembre

6

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Stefano Guido

Stefano Guido

12

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Nicola Brunetti-Pierri

Nicola Brunetti-Pierri

4

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Andrea Ballabio

Andrea Ballabio

17

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Eliezer Masliah

13

Eliezer Masliah

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13 September 2017

Alessandro Luciani

1

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13 September 2017

Valeria Rachela Villella

2

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13 September 2017

Speranza Esposito

3

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13 September 2017

Manuela Gavina

7

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13 September 2017

Laura Pulze

8

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13 September 2017

Ida Giardino

9

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13 September 2017

Massimo Pettoello-Mantovani

10

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13 September 2017

Maria D'Apolito

11

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13 September 2017

Brian Spencer

14

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13 September 2017

Sonia Quaratino

15

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13 September 2017

Valeria Raia

16

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13 September 2017

Luigi Maiuri

18

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13 September 2017

publication date

15 August 2010

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13 September 2017

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13 September 2017

volume

12

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13 September 2017

issue

9

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13 September 2017

page(s)

863-875

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Protein aggregate characterization in models of neurodegenerative disease

13 September 2017

cites work

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12 December 2020

Finally, mice with CF lung disease

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12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

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12 December 2020

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

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12 December 2020

The Beclin 1 interactome

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12 December 2020

Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates

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12 December 2020

Methods in mammalian autophagy research

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12 December 2020

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin

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12 December 2020

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

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12 December 2020

ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.

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12 December 2020

CFTR and chaperones: processing and degradation.

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12 December 2020

N-acetylcysteine inhibits Na+ absorption across human nasal epithelial cells

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12 December 2020

Azithromycin reduces spontaneous and induced inflammation in DeltaF508 cystic fibrosis mice

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12 December 2020

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

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12 December 2020

The autophagy effector Beclin 1: a novel BH3-only protein

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12 December 2020

Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa.

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12 December 2020

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

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12 December 2020

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

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12 December 2020

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

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12 December 2020

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

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12 December 2020

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

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12 December 2020

Single-dose lentiviral gene transfer for lifetime airway gene expression

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12 December 2020

Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication

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12 December 2020

The antioxidant function of the p53 tumor suppressor

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12 December 2020

Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge

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12 December 2020

CFTR is a negative regulator of NFkappaB mediated innate immune response

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12 December 2020

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.

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12 December 2020

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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12 December 2020

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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12 December 2020

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

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12 December 2020

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

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12 December 2020

CFTR function and prospects for therapy

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12 December 2020

Rescue of DeltaF508-CFTR by the SGK1/Nedd4-2 signaling pathway

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12 December 2020

Transglutaminases: crosslinking enzymes with pleiotropic functions

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12 December 2020

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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12 December 2020

p62 at the crossroads of autophagy, apoptosis, and cancer

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12 December 2020

Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis

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12 December 2020

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

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12 December 2020

Cytoprotective roles for autophagy

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12 December 2020

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

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12 December 2020

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

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12 December 2020

Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking

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12 December 2020

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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12 December 2020

Activation of the unfolded protein response by deltaF508 CFTR.

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12 December 2020

A role for ubiquitin in selective autophagy

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12 December 2020

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

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12 December 2020

Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy

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12 December 2020

Autophagy fights disease through cellular self-digestion

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12 December 2020

Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone

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12 December 2020

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

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12 December 2020

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12 December 2020

CFTR: new members join the fold.

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12 December 2020

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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12 December 2020

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

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12 December 2020

A critical role for CHIP in the aggresome pathway

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12 December 2020

Tissue transglutaminase inhibits autophagy in pancreatic cancer cells

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12 December 2020

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

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12 December 2020

Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation.

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12 December 2020

Transglutaminase is linked to neurodegenerative diseases

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12 December 2020

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

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12 December 2020

Autophagy suppresses tumorigenesis through elimination of p62

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12 December 2020

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

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12 December 2020

Self-eating and self-killing: crosstalk between autophagy and apoptosis

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12 December 2020

Identifiers

DOI

10.1038/NCB2090

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release_oxdokcv52jdrvcl3phi5n7zhny

13 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/oxdokcv52jdrvcl3phi5n7zhny

24 November 2022

mapped directly with Wikidata item

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