(Q39669749)

English

K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr virus (EBV)--associated nasopharyngeal carcinoma cells.

scientific article published on 7 August 2010

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20694504%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr virus (EBV)--associated nasopharyngeal carcinoma cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20694504%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Epstein–Barr virus

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1 reference

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inferred from title

Paul Bo-San Lai

10

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9 February 2020

12

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9 February 2020

9

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Chi-Man Tsang

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9 February 2020

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Yuen-Keng Ng

1

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9 February 2020

Elaine Yue Ling Wong

2

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9 February 2020

Cecilia Pik Yuk Lau

3

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9 February 2020

Jessica Pui Lan Chan

4

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9 February 2020

Sze Chuen Cesar Wong

5

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9 February 2020

Andrew Sai-Kit Chan

6

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9 February 2020

Maggie Pui Chun Kwan

7

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9 February 2020

Sai-Wah Tsao

8

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9 February 2020

Anthony Tak Cheung Chan

11

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9 February 2020

publication date

7 August 2010

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9 February 2020

Investigational New Drugs

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9 February 2020

30

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9 February 2020

1

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9 February 2020

48-58

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9 February 2020

https://scigraph.springernature.com/pub.10.1007/s10637-010-9513-4

0 references

Epstein-Barr virus in the pathogenesis of NPC.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

The Epstein-Barr virus: a group 1 carcinogen?

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Descriptive epidemiology and survival analysis of nasopharyngeal carcinoma in the United States

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Epstein-Barr virus carriage by nasopharyngeal carcinoma in situ

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Epstein-Barr virus DNA in nasopharyngeal carcinomas from Chinese patients in Hong Kong

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Transcriptional repression of tissue inhibitor of metalloproteinase-3 by Epstein-Barr virus latent membrane protein 1 enhances invasiveness of nasopharyngeal carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Nasopharyngeal carcinoma: current management, future directions and dental implications

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Disruption of epithelial cell-matrix interactions induces apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Understanding metastatic SCCHN cells from unique genotypes to phenotypes with the aid of an animal model and DNA microarray analysis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Acquisition of anoikis resistance reveals a synoikis-like survival style in BEL7402 hepatoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

In vitro and in vivo effects of bicalutamide on the expression of TrkA and P75 neurotrophin receptors in prostate carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

K252a inhibits the oncogenic properties of Met, the HGF receptor

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice

1 reference

https://api.crossref.org/works/10.1007%2FS10637-010-9513-4

21 January 2018

Nasopharyngeal cancer: epidemiology, staging, and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of Tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Expression and significance of tyrosine kinase receptors B in nasopharyngeal carcinoma patients]

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K252a inhibits proliferation of ovarian cancer cells by upregulating p21WAF1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotropins and their receptors are expressed in the human fetal ovary.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of CEP-751 (KT-6587) on human neuroblastoma and medulloblastoma xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K252a is highly effective in suppressing the growth of human endometrial cancer cells, but has little effect on normal human endometrial epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anoikis and metastatic potential of cloudman S91 melanoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nasopharyngeal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a, and its mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/20694504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-010-9513-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20694504%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20694504%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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