(Q39675037)

13 September 2017

title

Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth (English)

1 reference

13 September 2017

Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth (English)

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

11 June 2024

author name string

Josette Carnahan

1

1 reference

13 September 2017

Carol Babij

3

1 reference

13 September 2017

Quynh Le

4

1 reference

13 September 2017

Steven Vonderfecht

6

1 reference

13 September 2017

Karthik Nagapudi

9

1 reference

13 September 2017

Manory Fernando

11

1 reference

13 September 2017

Hue Kha

12

1 reference

13 September 2017

Brian Belmontes

13

1 reference

13 September 2017

Robert Radinsky

14

1 reference

13 September 2017

Richard Kendall

15

1 reference

13 September 2017

Pedro J. Beltran

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

Mark J. Rose

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

Joseph L. Kim

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

Adrian L. Smith

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

Martin A. Broome

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

Teresa L. Burgess

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

11 June 2024

language of work or name

1 reference

27 July 2010

1 reference

full work available at URL

13 September 2017

https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_from_Selective_and_Potent_Raf_Inhibitors_Paradoxically_Stimulate_Normal_Cell_Proliferation_and_Tumor_Growth/22484454/1/files/39935991.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

http://intl-mct.aacrjournals.org/cgi/content/abstract/9/8/2399

11 June 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663930

https://aacrjournals.org/mct/article-pdf/9/8/2399/1891388/2399.pdf

11 June 2024

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Molecular Cancer Therapeutics

11 June 2024

published in

1 reference

13 September 2017

volume

9

1 reference

13 September 2017

issue

8

1 reference

13 September 2017

page(s)

2399-2410

1 reference

Mutations of the BRAF gene in human cancer

13 September 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE00766

Raf kinases: function, regulation and role in human cancer

1

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

The MEK/ERK cascade: from signaling specificity to diverse functions

11 June 2024

2

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Endothelial apoptosis in Braf-deficient mice

11 June 2024

3

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Craf-1 protein kinase is essential for mouse development.

11 June 2024

4

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

11 June 2024

5

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

11 June 2024

6

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

11 June 2024

7

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

11 June 2024

8

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

11 June 2024

9

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

11 June 2024

10

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

11 June 2024

11

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Receptor tyrosine kinase inhibitors as potent weapons in war against cancers

11 June 2024

12

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery

11 June 2024

13

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

11 June 2024

14

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

The RAF proteins take centre stage

11 June 2024

16

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Discovery of a novel Raf kinase inhibitor

11 June 2024

17

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

11 June 2024

18

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors

11 June 2024

19

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

11 June 2024

20

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

11 June 2024

21

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

BRAF mutation predicts sensitivity to MEK inhibition

11 June 2024

22

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline

11 June 2024

25

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells

11 June 2024

26

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells

11 June 2024

27

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

11 June 2024

28

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor

11 June 2024

29

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

11 June 2024

31

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Epidermal growth factor receptor mutations in lung cancer

11 June 2024

32

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

11 June 2024

33

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Paradoxical activation of Raf by a novel Raf inhibitor

11 June 2024

34

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

11 June 2024

35

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

11 June 2024

37

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

11 June 2024

38

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Dermatologic symptoms associated with the multikinase inhibitor sorafenib

11 June 2024

40

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Localized palmar-plantar epidermal hyperplasia: a previously undefined dermatologic toxicity to sorafenib

11 June 2024

41

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib

11 June 2024

42

1 reference

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0181

11 June 2024

Identifiers

1 reference

13 September 2017

1 reference