(Q39704810)

14 September 2017

title

Bimodal expression of Sprouty2 during the cell cycle is mediated by phase-specific Ras/MAPK and c-Cbl activities (English)

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14 September 2017

6

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14 September 2017

Hedwig Sutterlüty-Fall

7

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14 September 2017

Michael Grusch

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author name string

Christoph-Erik Mayer

1

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14 September 2017

Barbara Haigl

2

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14 September 2017

Florian Jantscher

3

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14 September 2017

Gerald Siegwart

4

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14 September 2017

language of work or name

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12 May 2010

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Cellular and Molecular Life Sciences

14 September 2017

published in

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14 September 2017

volume

67

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14 September 2017

issue

19

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14 September 2017

page(s)

3299-3311

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0379-6

14 September 2017

exact match

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cites work

The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation

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12 December 2020

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation

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12 December 2020

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

12 December 2020

A negative feedback signaling network underlies oncogene-induced senescence

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12 December 2020

Growth-regulated antisense transcription of the mouse thymidine kinase gene

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12 December 2020

Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer.

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12 December 2020

Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation

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12 December 2020

ERK pathway positively regulates the expression of Sprouty genes

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12 December 2020

Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop

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12 December 2020

Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis

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12 December 2020

Cbl: many adaptations to regulate protein tyrosine kinases

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12 December 2020

Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.

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12 December 2020

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

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12 December 2020

Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

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12 December 2020

Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.

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12 December 2020

Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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12 December 2020

NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A.

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12 December 2020

Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation

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12 December 2020

Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.

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12 December 2020

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

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12 December 2020

Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

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12 December 2020

Evidence for direct interaction between Sprouty and Cbl

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12 December 2020

The C terminus of sprouty is important for modulation of cellular migration and proliferation.

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12 December 2020

Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

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12 December 2020

Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo

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12 December 2020

Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4.

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12 December 2020

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

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12 December 2020

Inhibition of angiogenesis by a mouse sprouty protein

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12 December 2020

Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling.

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12 December 2020

Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms

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12 December 2020

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

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12 December 2020

Regulation of sprouty stability by Mnk1-dependent phosphorylation

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12 December 2020

Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma.

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12 December 2020

Functional analysis of the human Sprouty2 gene promoter

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12 December 2020

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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12 December 2020

HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.

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12 December 2020

Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer

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12 December 2020

The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.

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12 December 2020

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

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12 December 2020

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

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12 December 2020

Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis

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12 December 2020

Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation

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12 December 2020

Differential display of genes expressed at the midbrain - hindbrain junction identifies sprouty2: an FGF8-inducible member of a family of intracellular FGF antagonists.

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12 December 2020

The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.

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12 December 2020

Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning

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12 December 2020

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.

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12 December 2020

Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2.

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12 December 2020

10.1007/S00018-010-0379-6

Identifiers

DOI

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14 September 2017

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