(Q39717036)

English

PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541.

scientific article published on 8 April 2010

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541. (English)

1 reference

Europe PubMed Central

14 September 2017

1 reference

based on heuristic

inferred from title

Daniel Hägerstrand

1

1 reference

Europe PubMed Central

14 September 2017

Maja Bradic Lindh

2

1 reference

Europe PubMed Central

14 September 2017

author name string

Cristina Peña

3

1 reference

Europe PubMed Central

14 September 2017

Carlos Garcia-Echeverria

4

1 reference

Europe PubMed Central

14 September 2017

Monica Nistér

5

1 reference

Europe PubMed Central

14 September 2017

Francesco Hofmann

6

1 reference

Europe PubMed Central

14 September 2017

Arne Ostman

7

1 reference

Europe PubMed Central

14 September 2017

publication date

8 April 2010

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

12

1 reference

Europe PubMed Central

14 September 2017

967-975

1 reference

Europe PubMed Central

14 September 2017

9

1 reference

Europe PubMed Central

14 September 2017

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

1 reference

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PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

1 reference

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Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine

1 reference

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Insulin and insulin-like growth factor signalling in neoplasia

1 reference

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

1 reference

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

1 reference

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

1 reference

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

1 reference

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

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Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer

1 reference

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

1 reference

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Genetic pathways to primary and secondary glioblastoma

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Insulin-like growth factor type I biology and targeting in malignant gliomas

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

1 reference

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PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

1 reference

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Type I insulin-like growth factor receptor as a therapeutic target in cancer

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

1 reference

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

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KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

1 reference

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Pathology and molecular genetics of astrocytic gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Insulin-like growth factor receptor-1 as an anti-cancer target: blocking transformation and inducing apoptosis

1 reference

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Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors

1 reference

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Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

1 reference

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Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib.

1 reference

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The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors

1 reference

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Cell proliferation and migration in glioblastoma multiforme cell lines are influenced by insulin-like growth factor I in vitro

1 reference

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Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

1 reference

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

1 reference

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Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors

1 reference

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p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Down-regulation of insulin-like growth factor I receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Characterization of an imatinib-sensitive subset of high-grade human glioma cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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PIK3CA mutations in glioblastoma multiforme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940698

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Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20378689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20378689

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NEUONC/NOQ029

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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