(Q39726060)

14 September 2017

title

Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism (English)

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14 September 2017

5

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14 September 2017

Youcef Mehellou

1

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Jan Balzarini

series ordinal

6

object named as

Jan Balzarini

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14 September 2017

7

Christopher McGuigan

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14 September 2017

Rocco Valente

2

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14 September 2017

Huw Mottram

series ordinal

3

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14 September 2017

Elisabeth Walsby

series ordinal

4

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14 September 2017

language of work or name

English

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publication date

1 March 2010

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Bioorganic & Medicinal Chemistry

14 September 2017

published in

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14 September 2017

volume

18

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14 September 2017

issue

7

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14 September 2017

page(s)

2439-2446

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Cytidine deaminase - the methodological relevance of AraC deamination for ex vivo experiments using cultured cell lines, fresh leukemic blasts, and normal bone marrow cells.

14 September 2017

cites work

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12 December 2020

Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells

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12 December 2020

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

1 reference

12 December 2020

Selenium derivatization and crystallization of DNA and RNA oligonucleotides for X-ray crystallography using multiple anomalous dispersion

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12 December 2020

Saturation of ara-CTP accumulation during high-dose ara-C therapy: pharmacologic rationale for intermediate-dose ara-C

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12 December 2020

Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

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12 December 2020

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency

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12 December 2020

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

1 reference

12 December 2020

Design, synthesis, and anti-HIV activity of 2′,3′-didehydro-2′,3′-dideoxyuridine (d4U), 2′,3′-dideoxyuridine (ddU) phosphoramidate ‘ProTide’ derivatives

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12 December 2020

Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery

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12 December 2020

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

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12 December 2020

Nucleoside analogues and nucleobases in cancer treatment.

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12 December 2020

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus

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12 December 2020

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

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12 December 2020

Molecular modelling studies on the binding of some protides to the putative human phosphoramidase Hint1.

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12 December 2020

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

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12 December 2020

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

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12 December 2020

10.1016/J.BMC.2010.02.059

Identifiers

DOI

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14 September 2017

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