(Q41984465)

English

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

scientific article published on 4 December 2006

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

anti-retroviral agent

0 references

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Tomáš Cihlář

6

object named as

Tomas Cihlar

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

author name string

Ruth Wang

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Xiaohong Liu

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Nilima Kutty

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Holly MacArthur

5

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Craig Gibbs

7

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Swami Swaminathan

8

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

William Lee

9

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Martin McDermott

10

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

0 references

publication date

4 December 2006

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

number of pages

8

1 reference

based on heuristic

inferred from page(s)

Antimicrobial Agents and Chemotherapy

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

51

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

543-550

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Tenofovir disoproxil fumarate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Lysosomal multienzyme complex: biochemistry, genetics, and molecular pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Cathepsin A/protective protein: an unusual lysosomal multifunctional protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Activity-based protein profiling: the serine hydrolases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Expression of protective protein in human tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Protective protein gene mutations in galactosialidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Serine carboxypeptidases: a new and versatile family of enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Molecular defect in combined beta-galactosidase and neuraminidase deficiency in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Human placental neuraminidase. Activation, stabilization and association with beta-galactosidase and its protective protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Human monocyte carboxylesterase. Purification and kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Inactivation of endothelin I by deamidase (lysosomal protective protein)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein"

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

5 June 2018

Structure determination of the human protective protein: twofold averaging reveals the three-dimensional structure of a domain which was entirely absent in the initial model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

18 August 2018

The mammalian carboxylesterases: from molecules to functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

18 August 2018

Inactivation of endothelin-1 by an enzyme of the vascular endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1797775

18 August 2018

A novel serine esterase expressed by cytotoxic T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human lysosomal beta-galactosidase-cathepsin A complex: definition of the beta-galactosidase-binding interface on cathepsin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficient lysosomal carboxypeptidase activity in galactosialidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elastase inhibitors for treatment of emphysema. Approaches to synthesis and biological evaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative modeling of substrate binding in the S1' subsite of serine carboxypeptidases from yeast, wheat, and human

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxypeptidases C and D

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of lysosomal protective protein in human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17145787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00968-06

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q41984465&oldid=1775251080"