(Q39737725)

14 September 2017

Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope (English)

1 reference

14 September 2017

4

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Siv A Hjorth

object named as

Siv A Hjorth

5

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author name string

Lishan Kang

1

1 reference

14 September 2017

Kent Bondensgaard

2

1 reference

14 September 2017

Tengkun Li

3

1 reference

14 September 2017

language of work or name

English

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publication date

18 February 2010

1 reference

Journal of Biological Chemistry

14 September 2017

1 reference

14 September 2017

285

1 reference

14 September 2017

16

1 reference

14 September 2017

12223-12231

1 reference

Structural biology of shared cytokine receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

14 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

14 September 2017

https://api.crossref.org/works/10.1074%2FJBC.M110.101444

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

A hot spot of binding energy in a hormone-receptor interface

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

Cytokine requirements for the growth and development of mouse NK cells in vitro.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852961

An antagonistic mutant of interleukin-4 fails to recruit gamma c into the receptor complex. Characterization by specific crosslinking

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20167599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20167599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional epitope of common gamma chain for interleukin-4 binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20167599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.101444

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

20167599

1 reference