(Q39752027)

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Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20074295%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20074295%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

apoptotic process

0 references

primary effusion lymphoma

1 reference

based on heuristic

inferred from title

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

author name string

A R Hussain

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

A S Khan

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

S O Ahmed

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

M Ahmed

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

L C Platanias

5

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

K S Al-Kuraya

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

publication date

14 January 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20074295%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Cell Proliferation

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

43

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

170-183

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

Tumorigenesis and aberrant signaling in transgenic mice expressing the human herpesvirus-8 K1 gene

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2009.00662.X

21 January 2018

A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2009.00662.X

21 January 2018

Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2009.00662.X

21 January 2018

A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2009.00662.X

21 January 2018

Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2009.00662.X

21 January 2018

Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IAP family proteins--suppressors of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin ligases: cell-cycle control and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal induction of adipogenesis induces Skp2 expression through PI3K and MAPK pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity and carcinogenicity studies of quercetin, a natural component of foods

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How to decrease p27Kip1 levels during tumor development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth inhibitory effects of flavonoids in human thyroid cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Chemopreventive Bioflavonoid Apigenin Modulates Signal Transduction Pathways in Keratinocyte and Colon Carcinoma Cell Lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 gene family and the regulation of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary effusion lymphoma (PEL) in HIV-negative patients--a distinct clinical entity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20074295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2184.2009.00662.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

release_xezc7sp44vgxpdj6qhvkn2je7q

1 reference

https://api.fatcat.wiki/v0/release/xezc7sp44vgxpdj6qhvkn2je7q

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6495730&resulttype=core&format=json

14 May 2020

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