(Q39753024)

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The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

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Europe PubMed Central

PubMed publication ID

14 September 2017

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

neuropathic pain

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Annette Dolphin

13

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

Alexandra Tran-Van-Minh

4

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15 May 2020

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

Laura Fernández-Alacid

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

Manuela Nieto-Rostro

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Manuela Nieto-Rostro

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15 May 2020

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Claudia S Bauer

1

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15 May 2020

Wahida Rahman

3

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15 May 2020

Laurent Ferron

5

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15 May 2020

Leon Douglas

6

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15 May 2020

Yorain Sri Ranjan

8

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15 May 2020

Neil S Millar

10

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15 May 2020

Anthony H Dickenson

11

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15 May 2020

Rafael Lujan

12

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15 May 2020

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publication date

1 April 2009

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Europe PubMed Central

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14 September 2017

Journal of Neuroscience

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15 May 2020

29

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15 May 2020

13

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

4076-4088

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6665374/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6665374/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated administration of systemic gabapentin alleviates allodynia-like behaviors in spinally injured rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and regulation of voltage-gated Ca2+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Streptozocin-induced neuropathy is associated with altered expression of voltage-gated calcium channel subunit mRNAs in rat dorsal root ganglion neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology of neuropathic pain: mode of action of anticonvulsants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Distribution of &mgr; and delta Opioid Binding Sites Belonging to a Single Cervical Dorsal Root in the Superficial Dorsal Horn of the Rat Spinal Cord: A Quantitative Autoradiographic Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin-- actions on adult superficial dorsal horn neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type Ca2+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta subunits of voltage-gated calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium channel alpha2delta subunits: differential expression, function, and drug binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptive response to innocuous mechanical stimulation is mediated via myelinated afferents and NK-1 receptor activation in a rat model of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bad news from the brain: descending 5-HT pathways that control spinal pain processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of the antinociceptive action of gabapentin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting chronic and neuropathic pain: the N-type calcium channel comes of age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ducky(2J) mutation in Cacna2d2 results in reduced spontaneous Purkinje cell activity and altered gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[3H] pregabalin binding is increased in ipsilateral dorsal horn following chronic constriction injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unmyelinated primary afferents from adjacent spinal nerves intermingle in the spinal dorsal horn: a possible mechanism contributing to neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of neuropathic pain in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course and specificity of the pharmacological disruption of the trafficking of voltage-gated calcium channels by gabapentin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatotopic organization of cutaneous afferent terminals and dorsal horn neuronal receptive fields in the superficial and deep laminae of the rat lumbar spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethical guidelines for investigations of experimental pain in conscious animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of the [3H]gabapentin-binding protein/alpha 2 delta Ca2+ channel subunit from porcine brain: development of a radioligand binding assay for alpha 2 delta subunits using [3H]leucine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of human neuronal alpha 1E-type calcium channel by alpha 2 delta-subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of overexpression of auxiliary Ca2+ channel subunits on native Ca2+ channel currents in undifferentiated mammalian NG108-15 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19339603

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0356-09.2009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665374&resulttype=core&format=json

15 May 2020

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