(Q39754378)

14 September 2017

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title

Clinical pharmacokinetics of verapamil, nifedipine and diltiazem (English)

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14 September 2017

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H Echizen

1

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14 September 2017

M Eichelbaum

series ordinal

2

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14 September 2017

publication date

1 November 1986

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Clinical Pharmacokinetics

14 September 2017

published in

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14 September 2017

volume

11

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14 September 2017

issue

6

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14 September 2017

page(s)

425-449

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Pharmacokinetics and metabolism of diltiazem in man

14 September 2017

cites work

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12 December 2020

Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris

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12 December 2020

Determination of nifedipine in serum or plasma by reversed-phase liquid chromatography

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12 December 2020

Pharmacokinetic studies of nifedipine tablet. Correlation with antihypertensive effects

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12 December 2020

Pharmacokinetics and metabolism of nifedipine

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12 December 2020

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

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12 December 2020

Analysis of verapamil in plasma by liquid chromatography

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12 December 2020

Correlation of plasma levels of nifedipine and cardiovascular effects after sublingual dosing in normal subjects

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12 December 2020

An investigation of the cause of accumulation of verapamil during regular dosing in patients

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12 December 2020

Hemodynamic effects of intravenous diltiazem in patients treated chronically with propranolol.

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12 December 2020

Cerebral Arterial Spasm – A Controlled Trial of Nimodipine in Patients with Subarachnoid Hemorrhage

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12 December 2020

High-performance liquid chromatography of nifedipine, its metabolites and photochemical degradation products

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12 December 2020

Diltiazem and desacetyldiltiazem analysis in human plasma using high-performance liquid chromatography: improved sensitivity without derivation

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12 December 2020

The pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses

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12 December 2020

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part I: Basic and Clinical Electrophysiologic Effects

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12 December 2020

Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism

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12 December 2020

Nifedipine: kinetics and dynamics in healthy subjects

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12 December 2020

The Pharmacology of Verapamil. III. Pharmacokinetics in Normal Subjects After Intravenous Drug Administration

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12 December 2020

Simultaneous determination of verapamil and its seven metabolites by high-performance liquid chromatography

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12 December 2020

Rapid high-performance liquid chromatographic method for the measurement of verapamil and norverapamil in blood plasma or serum

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12 December 2020

Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man

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12 December 2020

The Beneficial Effects of Verapamil in Chronic Atrial Fibrillation

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12 December 2020

Pharmacokinetics of diltiazem after intravenous and oral administration

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12 December 2020

Plasma verapamil levels and exercise performance

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12 December 2020

Verapamil for control of ventricular rate in paroxysmal supraventricular tachycardia and atrial fibrillation or flutter: a double-blind randomized cross-over study

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12 December 2020

Inter- and intra-subject variation in the first-pass elimination of highly cleared drugs during chronic dosing. Studies with deuterated verapamil

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12 December 2020

Determination of nifedipine in human plasma by capillary gas chromatography with nitrogen detection

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12 December 2020

High-performance liquid chromatographic analysis of diltiazem and its metabolite in plasma

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12 December 2020

Physiological disposition of verapamil in man

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12 December 2020

Verapamil kinetics in normal subjects and patients with coronary artery spasm

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12 December 2020

Lack of effects of diltiazem on digoxin pharmacokinetics.

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12 December 2020

Verapamil in Prophylaxis of Paroxysmal Atrioventricular Nodal Reentrant Tachycardia

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12 December 2020

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study

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12 December 2020

Prolongation of verapamil elimination kinetics during chronic oral administration

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12 December 2020

Metabolic Fate of <I>d-cis</I>-3-Acetoxy-5-[2-(dimethylamino) ethyl]-2, 3-dihydro-2-(<I>p</I>-methoxyphenyl)-1, 5-benzothiazepin-4 (5H)-one Hydrochloride (CRD-401)

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12 December 2020

Serum concentration and antihypertensive effect of slow-release verapamil

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12 December 2020

Effects of nifedipine and diltiazem on plasma levels and renal excretion of beta-acetyldigoxin

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12 December 2020

Acute and chronic pharmacodynamic interaction of verapamil and digoxin in atrial fibrillation

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12 December 2020

Haemodialysis does not affect the pharmacokinetics of nifedipine

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12 December 2020

Quantitation of diltiazem and desacetyldiltiazem in dog plasma by high-performance liquid chromatography

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12 December 2020

The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans

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12 December 2020

Pharmacokinetics of verapamil in patients with renal failure.

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12 December 2020

Calcium Antagonists Pharmacodynamic Effects and Mechanism of Action

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12 December 2020

Rapid GC method for quantitation of nifedipine in serum using electron capture detection

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12 December 2020

Defective oxidation of drugs: pharmacokinetic and therapeutic implications

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12 December 2020

Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination. Studies of the relative bioavailability of verapamil tablets

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12 December 2020

Simultaneous quantitation of verapamil, norverapamil, and N-dealkylated metabolites in human plasma following oral administration

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12 December 2020

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

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12 December 2020

Acute and long-term hypotensive effects and plasma concentrations of nifedipine in patients with essential hypertension

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12 December 2020

Intravenous verapamil for termination of re-entrant supraventricular tachycardias: intracardiac studies correlated with plasma verapamil concentrations

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12 December 2020

Plasma Concentration-Response Relationship of Verapamil in the Treatment of Angina Pectoris

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12 December 2020

Effect of nifedipine on digoxin kinetics in healthy subjects

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12 December 2020

Effects of nifedipine on esophageal motor function in humans: correlation with plasma nifedipine concentration

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12 December 2020

Pharmacokinetics of diltiazem in severe renal failure

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12 December 2020

Verapamil disposition kinetics in chronic atrial fibrillation

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12 December 2020

Verapamil--a potent inhibitor of esophageal contractions in the baboon

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12 December 2020

Determination of verapamil in human plasma by mass fragmentography using stable isotope-labelled verapamil as internal standard

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12 December 2020

Pharmacokinetics of verapamil in man

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12 December 2020

Clinical pharmacokinetics of verapamil in patients with atrial fibrillation

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12 December 2020

Acute and chronic effects of nifedipine in arterial hypertension

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12 December 2020

The pharmacology of verapamil. I. Elimination kinetics in dogs and correlation of plasma levels with effect on the eletrocardiogram

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12 December 2020

Lack of interaction between verapamil and cimetidine.

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12 December 2020

Reversed-phase high performance liquid chromatographic determination of nifedipine in human plasma

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12 December 2020

Nifedipine and beta-blockade as a cause of cardiac failure

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12 December 2020

Influence of meso-caval shunt surgery on verapamil kinetics, bioavailability and response

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12 December 2020

High-performance liquid chromatographic analysis of verapamil. II. Simultaneous quantitation of verapamil and its active metabolite, norverapamil

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12 December 2020

Protein binding of nifedipine

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12 December 2020

High-performance liquid chromatographic determination of diltiazem and six of its metabolites in human urine

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12 December 2020

Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique

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12 December 2020

Digoxin-verapamil interaction

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12 December 2020

Primary pulmonary hypertension: effects of nifedipine

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12 December 2020

Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil.

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12 December 2020

Comparative cardiovascular actions of verapamil and its major metabolites in the anaesthetised dog.

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12 December 2020

Prediction of steady-state verapamil plasma concentrations in children and adults.

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12 December 2020

Identification of nifedipine metabolites and their determination by gas chromatography

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12 December 2020

Digoxin-diltiazem interaction

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12 December 2020

Cardiovascular effects of the metabolites of diltiazem in dogs.

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12 December 2020

Studies on the metabolism of diltiazem in man

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12 December 2020

Verapamil plasma binding: relationship to alpha 1-acid glycoprotein and drug efficacy.

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12 December 2020

The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects

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12 December 2020

Pharmacokinetic model of diltiazem.

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12 December 2020

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

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12 December 2020

Verapamil plasma levels and ventricular rate response in patients with atrial fibrillation and flutter

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12 December 2020

Nifedipine kinetics and bioavailability after single intravenous and oral doses in normal subjects

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12 December 2020

Verapamil disposition--effects of sulphinpyrazone and cimetidine

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12 December 2020

Effect of cimetidine on verapamil disposition.

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12 December 2020

Effects of oral calcium blocker, diltiazem, on esophageal contractions. Studies in volunteers and patients with nutcracker esophagus

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12 December 2020

Nifedipine and left ventricular function in beta-blocked patients

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12 December 2020

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis

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12 December 2020

Comparison of the electrophysiologic effects of intravenous and oral verapamil in patients with paroxysmal supraventricular tachycardia

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12 December 2020

Gas chromatographic determination of nifedipine and one of its metabolites using electron capture detection

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12 December 2020

Verapamil protein binding in patients and in normal subjects

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12 December 2020

Verapamil and norverapamil plasma concentrations during long-term therapy in patients with hypertrophic obstructive cardiomyopathy

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12 December 2020

The metabolism of DL-[14C]verapamil in man

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12 December 2020

The influence of verapamil on serum digoxin concentration

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12 December 2020

Liquid chromatographic determination of nifedipine in plasma and of its main metabolite in urine

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12 December 2020

Improved gas chromatographic determination of diltiazem and deacetyldiltiazem in human plasma

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12 December 2020

Interaction between digoxin and nifedipine at steady state in patients with atrial fibrillation

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12 December 2020

Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications

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12 December 2020

Verapamil disposition in liver disease and intensive-care patients: kinetics, clearance, and apparent blood flow relationships

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12 December 2020

Pharmacokinetic and pharmacodynamic effects of diltiazem

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12 December 2020

High-performance liquid chromatographic determination of diltiazem and four of its metabolites in plasma. Application to pharmacokinetics

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12 December 2020

Gas chromatographic determination of verapamil in plasma and urine

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12 December 2020

Combined therapy with verapamil and propranolol in chronic stable angina

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12 December 2020

Clinical applications of slow channel blocking compounds

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12 December 2020

Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog

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12 December 2020

Treatment of supraventricular arrhythmias with intravenous and oral verapamil

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12 December 2020

Factors affecting the plasma protein binding of verapamil and norverapamil in man

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12 December 2020

The first pass metabolism of nifedipine in man.

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12 December 2020

Interaction between digoxin and calcium antagonists and antiarrhythmic drugs

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12 December 2020

[The binding of 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (nifedipine) as well as other coronary active substances to serum albumins]

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12 December 2020

Plasma nifedipine levels and fall in blood pressure in a 53 year old woman

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12 December 2020

Clinical use of a calcium antagonistic agent (nifedipine) in acute pulmonary edema

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12 December 2020

Direct determination of hepatic extraction of verapamil in cardiac patients

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12 December 2020

Pharmacokinetics of verapamil: experience with a sustained intravenous infusion regimen

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12 December 2020

Systemic availability of oral verapamil and effect on PR interval in man

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12 December 2020

Pharmacodynamic aspects of intravenous diltiazem administration

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12 December 2020

Effect of nifedipine on plasma renin, aldosterone and catecholamines in arterial hypertension

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12 December 2020

Calcium antagonists. Clinical use in the treatment of arrhythmias

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12 December 2020

Occurrence and measurement of nifedipine and its nitropyridine derivatives in human blood plasma

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12 December 2020

Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders

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12 December 2020

Pharmacodynamic comparison of oral and intravenous verapamil in atrial fibrillation

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12 December 2020

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man

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12 December 2020

Quantitative determination of nifedipine in human plasma by selected ion monitoring

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12 December 2020

Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship

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12 December 2020

Relationship between the antihypertensive effect and steady-state plasma concentration of nifedipine given alone or in combination with a beta-adrenoceptor blocking agent

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12 December 2020

Relationship Between Plasma Diltiazem and Cardiovascular Responses in Conscious Dogs

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12 December 2020

High-performance liquid chromatographic measurement of verapamil in plasma using a diol column

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12 December 2020

Verapamil prophylaxis of migraine. A double-blind, placebo-controlled study

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12 December 2020

Reduced verapamil clearance during long-term oral administration

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12 December 2020

The pharmacokinetics and pharmacology of oral diltiazem in normal volunteers

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12 December 2020

Effect of diltiazem on renal clearance and serum concentration of digoxin in patients with cardiac disease

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12 December 2020

Plasma concentrations of nifedipine in patients with renal failure

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12 December 2020

Clinical study on the pharmacokinetics of radioactively labelled 4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester

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12 December 2020

Serum binding of diltiazem in humans

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12 December 2020

10.2165/00003088-198611060-00002

Identifiers

DOI

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Dimensions Publication ID

14 September 2017

1051791918

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