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Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
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PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
title
Hypoxia-activated Smad3-specific dephosphorylation by PP2A
(English)
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Europe PubMed Central
PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
main subject
hypoxia
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Caroline S. Hill
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5
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Europe PubMed Central
PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
Pekka T Heikkinen
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1
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Europe PubMed Central
PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
Suvi-Katri Leivonen
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3
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2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
Jukka Westermarck
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4
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13 February 2020
Veli-Matti Kähäri
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6
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Europe PubMed Central
PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
Panu M Jaakkola
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7
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2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
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Marika Nummela
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2
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2823515
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13 February 2020
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1 December 2009
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2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
published in
Journal of Biological Chemistry
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2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
volume
285
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Europe PubMed Central
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2823515
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13 February 2020
issue
6
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Europe PubMed Central
PMC publication ID
2823515
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
page(s)
3740-3749
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Europe PubMed Central
PMC publication ID
2823515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
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13 February 2020
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2823515/fullTextXML
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cites work
PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1.
1 reference
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Effects of hypoxia on expression of transforming growth factor-beta1 and its receptors I and II in the amoeboid microglial cells and murine BV-2 cells
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22 September 2017
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.
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22 September 2017
PP2A: unveiling a reluctant tumor suppressor
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Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
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Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling
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Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
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22 September 2017
Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.
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22 September 2017
Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823515
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Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription.
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Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells
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New insights into TGF-beta-Smad signalling
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Identification of specific PP2A complexes involved in human cell transformation
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22 September 2017
GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor
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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
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22 September 2017
Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4
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22 September 2017
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823515
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823515
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Cellular response to hypoxia involves signaling via Smad proteins
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823515
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Smad regulation in TGF-beta signal transduction
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TGF-beta signaling in tumor suppression and cancer progression
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1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19951945
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1074/JBC.M109.042978
1 reference
stated in
Europe PubMed Central
PMC publication ID
2823515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PMC publication ID
2823515
1 reference
stated in
Europe PubMed Central
PMC publication ID
2823515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PubMed publication ID
19951945
1 reference
stated in
Europe PubMed Central
PMC publication ID
2823515
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19951945%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
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