(Q39769285)

14 September 2017

title

Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome (English)

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14 September 2017

Mark C Bagley

1

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14 September 2017

Terence Davis

2

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14 September 2017

Matthew C Dix

3

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14 September 2017

Vincenzo Fusillo

4

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14 September 2017

Morgane Pigeaux

5

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14 September 2017

Michal J Rokicki

6

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14 September 2017

David Kipling

7

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14 September 2017

publication date

1 September 2010

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Future Medicinal Chemistry

14 September 2017

published in

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14 September 2017

volume

2

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14 September 2017

issue

9

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14 September 2017

page(s)

1417-1427

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What geriatricians should know about the Werner syndrome

14 September 2017

cites work

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

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Replicative senescence: an old lives' tale?

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How might replicative senescence contribute to human ageing?

21 January 2018

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What can progeroid syndromes tell us about human aging?

21 January 2018

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Positional cloning of the Werner's syndrome gene

21 January 2018

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Extension of the life span in patients with Werner syndrome

21 January 2018

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Early amelioration of insulin resistance and reduction of interleukin-6 in Werner syndrome using pioglitazone

21 January 2018

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Vitamin C restores healthy aging in a mouse model for Werner syndrome

21 January 2018

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Werner Syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome?

21 January 2018

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Asymmetry of DNA replication fork progression in Werner's syndrome

21 January 2018

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Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

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An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

21 January 2018

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Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing

21 January 2018

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Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

21 January 2018

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Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745.

21 January 2018

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Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome

21 January 2018

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Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells

21 January 2018

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Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells

21 January 2018

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Smurf1: a link between cell polarity and ubiquitination.

21 January 2018

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Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

21 January 2018

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A mouse model of Werner Syndrome: what can it tell us about aging and cancer?

21 January 2018

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Microwave dielectric heating in synthetic organic chemistry

21 January 2018

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Controlled microwave heating in modern organic synthesis.

21 January 2018

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The impact of microwave synthesis on drug discovery.

21 January 2018

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Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines.

21 January 2018

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Recent applications of microwave irradiation to medicinal chemistry

21 January 2018

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Microwave energy: a versatile tool for the biosciences

21 January 2018

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A simple continuous flow microwave reactor.

21 January 2018

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Continuous flow processing from microreactors to mesoscale: the Bohlmann-Rahtz cyclodehydration reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

Prevention of accelerated cell aging in the Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development

21 January 2018

1 reference

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P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis

21 January 2018

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Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders

21 January 2018

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Inhibition of p38: has the fat lady sung?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

The use of microwave ovens for rapid organic synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

Application of commercial microwave ovens to organic synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

Scale-up of Microwave-Assisted Polymerizations in Batch Mode: The Cationic Ring-Opening Polymerization of 2-Ethyl-2-oxazoline

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.217

21 January 2018

Identifiers

DOI

10.4155/FMC.10.217

1 reference

release_cf5rmwizofcippk2lictv3v6l4

14 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cf5rmwizofcippk2lictv3v6l4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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