(Q39770887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19937668%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1 (English)

1 reference

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12 February 2020

1

1 reference

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12 February 2020

Simranjeet Kaur

5

1 reference

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12 February 2020

Nilanjan Roy

6

1 reference

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12 February 2020

Nilanjan Roy

7

1 reference

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Anabela Cordeiro-da-Silva

12 February 2020

8

1 reference

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12 February 2020

author name string

Ali Ouaissi

2

1 reference

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12 February 2020

Paul Kong Thoo Lin

3

1 reference

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12 February 2020

Inês Loureiro

4

1 reference

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12 February 2020

publication date

1 January 2010

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12 February 2020

1 reference

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12 February 2020

volume

5

1 reference

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12 February 2020

issue

1

1 reference

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12 February 2020

page(s)

140-147

1 reference

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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

12 February 2020

cites work

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

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Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine

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7 January 2021

SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates

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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

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SIRT1 regulates HIV transcription via Tat deacetylation

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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7 January 2021

Acetylation inactivates the transcriptional repressor BCL6.

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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

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Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

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Identification of a small molecule inhibitor of Sir2p

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7 January 2021

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

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7 January 2021

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

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7 January 2021

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

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7 January 2021

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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7 January 2021

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

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7 January 2021

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

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7 January 2021

Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death.

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7 January 2021

Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation.

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7 January 2021

The Leishmania infantum cytosolic SIR2-related protein 1 (LiSIR2RP1) is an NAD+ -dependent deacetylase and ADP-ribosyltransferase

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7 January 2021

Differential effects of polyamine derivative compounds against Leishmania infantum promastigotes and axenic amastigotes

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7 January 2021

The synthesis and in vitro cytotoxic studies of novel bis-naphthalimidopropyl polyamine derivatives

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7 January 2021

The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum

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7 January 2021

Synthesis and biological activities of bisnaphthalimido polyamines derivatives: cytotoxicity, DNA binding, DNA damage and drug localization in breast cancer MCF 7 cells.

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7 January 2021

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

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7 January 2021

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

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7 January 2021

Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases

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7 January 2021

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

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7 January 2021

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7 January 2021

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

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7 January 2021

Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery

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7 January 2021

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7 January 2021

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7 January 2021

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