(Q39804575)

14 September 2017

Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus (English)

1 reference

14 September 2017

Koichiro Yamada

1

1 reference

14 September 2017

Tomonori Tsukahara

2

1 reference

14 September 2017

Kazuhisa Yoshino

3

1 reference

14 September 2017

Katsuhiko Kojima

4

1 reference

14 September 2017

Hideyuki Agawa

5

1 reference

14 September 2017

Yuki Yamashita

6

1 reference

14 September 2017

Yuji Amano

7

1 reference

14 September 2017

Mariko Hatta

8

1 reference

14 September 2017

Yasunori Matsuzaki

9

1 reference

14 September 2017

Naoki Kurotori

10

1 reference

14 September 2017

Keiko Wakui

11

1 reference

14 September 2017

Yoshimitsu Fukushima

12

1 reference

14 September 2017

Ryosuke Osada

13

1 reference

14 September 2017

Tanri Shiozawa

14

1 reference

14 September 2017

Kazuo Sakashita

15

1 reference

14 September 2017

Kenichi Koike

16

1 reference

14 September 2017

Satoru Kumaki

17

1 reference

14 September 2017

Nobuyuki Tanaka

18

1 reference

14 September 2017

Toshikazu Takeshita

19

1 reference

14 September 2017

language of work or name

1 reference

2 September 2009

1 reference

14 September 2017

1 reference

14 September 2017

6

1 reference

14 September 2017

79

1 reference

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Hot spots of retroviral integration in human CD34+ hematopoietic cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Selection of target sites for mobile DNA integration in the human genome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Genome-wide analysis of retroviral DNA integration

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Transcription start regions in the human genome are favored targets for MLV integration

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Cloning of the gamma chain of the human IL-2 receptor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

Gene therapy insertional mutagenesis insights

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2742512

20 August 2018

Identifiers

DOI

10.1186/1742-4690-6-79

1 reference

Dimensions Publication ID

14 September 2017

1016034898

0 references

Fatcat ID

release_pbtgavueqvbp5f5zmyf74yjdei

0 references

1 reference

14 September 2017

PubMed publication ID

19725963

1 reference