(Q36921957)

17 August 2017

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title

New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy (English)

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17 August 2017

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Mirjam van der Burg

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17 August 2017

Jacques J M van Dongen

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4

object named as

Jacques J M van Dongen

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17 August 2017

Karin Pike-Overzet

1

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17 August 2017

Gerard Wagemaker

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3

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17 August 2017

Frank J T Staal

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5

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17 August 2017

28 August 2007

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17 August 2017

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17 August 2017

15

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11

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17 August 2017

1910-1916

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Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

17 August 2017

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Murine leukemia induced by retroviral gene marking

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy. Second child in French trial is found to have leukemia

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

A new modality for immunosuppression: targeting the JAK/STAT pathway

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy for severe combined immunodeficiency: are we there yet?

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy of X-linked severe combined immunodeficiency

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

T-sing progenitors to commit

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Thymopoiesis independent of common lymphoid progenitors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

RAG mutations in human B cell-negative SCID.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Differential biological role of CD3 chains revealed by human immunodeficiencies

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy insertional mutagenesis insights

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy: therapeutic gene causing lymphoma

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy: is IL2RG oncogenic in T-cell development?

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Gene therapy: X-SCID transgene leukaemogenicity

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Acute monoblastic leukemia of infancy in Klinefelter's syndrome

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Long-term immune reconstitution in RAG-1-deficient mice treated by retroviral gene therapy: a balance between efficiency and toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300297

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300297

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17 August 2017

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