(Q39810440)

14 September 2017

title

Effect of food and gemfibrozil on the pharmacokinetics of the novel prolyl hydroxylase inhibitor GSK1278863. (English)

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14 September 2017

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Brendan M Johnson

1

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14 September 2017

Brendt A Stier

series ordinal

2

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14 September 2017

Stephen Caltabiano

series ordinal

3

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14 September 2017

publication date

22 October 2013

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Clinical pharmacology in drug development

14 September 2017

published in

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14 September 2017

volume

3

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14 September 2017

issue

2

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14 September 2017

page(s)

109-117

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Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

14 September 2017

cites work

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The HIF pathway and erythrocytosis

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

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HIF prolyl hydroxylase inhibitors for anemia

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Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

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Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

21 January 2018

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Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

21 January 2018

1 reference

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone

21 January 2018

1 reference

Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast

21 January 2018

1 reference

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

21 January 2018

1 reference

Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

21 January 2018

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The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

21 January 2018

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Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs

21 January 2018

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Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively

21 January 2018

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The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.

21 January 2018

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Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency

21 January 2018

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7 January 2021

Role of hypoxia in the pathogenesis of renal disease

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7 January 2021

Statistical analysis of bioavailability studies: parametric and nonparametric confidence intervals

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7 January 2021

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

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7 January 2021

Identifiers

DOI

10.1002/CPDD.83

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14 September 2017

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