(Q40074903)

English

Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

0 references

drug interaction

0 references

drug metabolism

1 reference

based on heuristic

inferred from title

Aleksandra Galetin

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Laura K Hinton

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

J Brian Houston

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

27 September 2007

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

25

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1063-1074

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9446-6

21 January 2018

Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of glimepiride

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil greatly increases plasma concentrations of cerivastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of itraconazole metabolites in CYP3A4 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug interaction studies: study design, data analysis, and implications for dosing and labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of gemfibrozil on the pharmacokinetics of pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BacMam recombinant baculovirus in transporter expression: a study of BCRP and OATP1B1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporine markedly raises the plasma concentrations of repaglinide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of transporters and enzymes in hepatic drug processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Pharmacokinetics of Atorvastatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--towards a consensus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic disposition of the acyl glucuronide1-O-gemfibrozil-beta-D-glucuronide: effects of dibromosulfophthalein on membrane transport and aglycone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transporters as a determinant of drug clearance and tissue distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of active simvastatin acid are increased by gemfibrozil

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of fibrates on metabolism of statins in human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of pravastatin sodium in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17901929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-007-9446-6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901929%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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