(Q37779100)

English

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

scientific article published on September 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 August 2017

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Europe PubMed Central

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

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author name string

Lin Yan

1

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Vincent J Colandrea

2

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Europe PubMed Central

PubMed publication ID

23 August 2017

Jeffrey J Hale

3

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Europe PubMed Central

PubMed publication ID

23 August 2017

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publication date

1 September 2010

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Europe PubMed Central

PubMed publication ID

23 August 2017

Expert Opinion on Therapeutic Patents

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Europe PubMed Central

PubMed publication ID

23 August 2017

20

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Europe PubMed Central

PubMed publication ID

23 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

1219-1245

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structure and mechanism of haemoglobin

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Plasma erythropoietin in chronic uraemia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Cloning and expression of the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Developments in the therapeutic use of erythropoiesis stimulating agents

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Healthcare expenditure and resource utilization in patients with anaemia and chronic kidney disease: a retrospective claims database analysis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Purification and characterization of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of angiogenesis by oxygen sensing mechanisms

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structure and signaling mechanism of Per-ARNT-Sim domains

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Role of the hypoxia inducible factors HIF in iron metabolism.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Signalling hypoxia by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Nuclear oxygen sensing: induction of endogenous prolyl-hydroxylase 2 activity by hypoxia and nitric oxide

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIF prolyl 4-hydroxylases and their potential as drug targets

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Activation of HIF-1alpha mRNA by hypoxia and iron chelator in isolated rat carotid body

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Characterization of a robust enzymatic assay for inhibitors of 2-oxoglutarate-dependent hydroxylases.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Therapeutic manipulation of the HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Hypoxic tumor microenvironment and cancer cell differentiation

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Role of hypoxia in the hallmarks of human cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIF-1 and tumor progression: pathophysiology and therapeutics

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Role of VHL gene mutation in human cancer

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

The von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

PHD2 mutation and congenital erythrocytosis with paraganglioma.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Relationship of site-specific cancer mortality rates to altitude.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Altitude, radiation, and mortality from cancer and heart disease.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Erythropoietin and tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Disturbance in the HIF-1alpha pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Role of oxygen in cancer: looking beyond hypoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Daily aspirin--only half the answer

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Genetic causes of erythrocytosis and the oxygen-sensing pathway

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Molecular mechanisms of pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

High-Altitude Illness

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

High-altitude pulmonary hypertension: a pathophysiological entity to different diseases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Pulmonary hypertension and erythropoietin

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Emerging therapies for pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

HIF prolyl-4-hydroxylase interacting proteins: consequences for drug targeting.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Expanding chemical biology of 2-oxoglutarate oxygenases

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.510836

21 January 2018

Identifiers

10.1517/13543776.2010.510836

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

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