(Q34132816)

31 July 2017

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title

The von Hippel-Lindau tumor suppressor protein (English)

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31 July 2017

2

W G Kaelin

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31 July 2017

M Ivan

1

1 reference

31 July 2017

1 February 2001

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Current Opinion in Genetics & Development

31 July 2017

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31 July 2017

11

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31 July 2017

27-34

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31 July 2017

1

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A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Inhibition of transcription elongation by the VHL tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Ubiquitin-mediated proteolysis: biological regulation via destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Polycythemia: mechanisms and management

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Evolution and function of ubiquitin-like protein-conjugation systems

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

von Hippel-Lindau Protein Induces Hypoxia-regulated Arrest of Tyrosine Hydroxylase Transcript Elongation in Pheochromocytoma Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Moving protein heads for breakdown

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Comparative sequence analysis of the VHL tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Renal cysts, renal cancer and von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

Many vessels, faulty gene

1 reference

https://api.crossref.org/works/10.1016%2FS0959-437X%2800%2900152-0

7 January 2021

10.1016/S0959-437X(00)00152-0

Identifiers

DOI

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31 July 2017

1 reference

PubMed ID

11163147