(Q39812900)

English

N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1 (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

apoptotic process

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6

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5 February 2020

Alicja Trebinska

2

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5 February 2020

3

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5 February 2020

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Bengt Fadeel

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5 February 2020

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Siriporn Jitkaew

1

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5 February 2020

Göran Carlsson

4

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5 February 2020

Anders Nordström

5

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5 February 2020

Anne-Sophie Fröjmark

7

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Europe PubMed Central

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5 February 2020

Niklas Dahl

8

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5 February 2020

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publication date

13 August 2009

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5 February 2020

Journal of Biological Chemistry

1 reference

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5 February 2020

284

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5 February 2020

41

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

27827-27837

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

N-acetylcysteine blocks apoptosis induced by N-alpha-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

TRANSFAC: a database on transcription factors and their DNA binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

22 September 2017

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

25 September 2017

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

17 June 2018

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

17 June 2018

Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

20 August 2018

Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

20 August 2018

Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

20 August 2018

Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

20 August 2018

AliBaba2: context specific identification of transcription factor binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2788833

20 August 2018

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence for the presence of histidine in the active center of chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A routine method for the establishment of permanent growing lymphoblastoid cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and expression analysis of alternative splice variants of the rat Hax-1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19679660

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.027912

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19679660%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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