(Q39818021)

English

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors (English)

1 reference

Europe PubMed Central

14 September 2017

Dennis C. Liotta

15

object named as

Dennis C Liotta

1 reference

Europe PubMed Central

14 September 2017

Praseeda Mullasseril

7

object named as

Praseeda Mullasseril

1 reference

Europe PubMed Central

14 September 2017

Rose Santangelo

4

object named as

Rose Santangelo

1 reference

Europe PubMed Central

14 September 2017

1

object named as

Cara A Mosley

1 reference

Europe PubMed Central

14 September 2017

Polina Lyuboslavsky

9

object named as

Polina Lyuboslavsky

1 reference

Europe PubMed Central

14 September 2017

8

object named as

Hongjie Yuan

1 reference

Europe PubMed Central

14 September 2017

Yesim A Tahirovic

5

object named as

Yesim A Tahirovic

1 reference

Europe PubMed Central

14 September 2017

author name string

Scott J Myers

2

1 reference

Europe PubMed Central

14 September 2017

Ernest E Murray

3

1 reference

Europe PubMed Central

14 September 2017

Natalie Kurtkaya

6

1 reference

Europe PubMed Central

14 September 2017

Phuong Le

10

1 reference

Europe PubMed Central

14 September 2017

Lawrence J Wilson

11

1 reference

Europe PubMed Central

14 September 2017

Manuel Yepes

12

1 reference

Europe PubMed Central

14 September 2017

Ray Dingledine

13

1 reference

Europe PubMed Central

14 September 2017

Stephen F Traynelis

14

1 reference

Europe PubMed Central

14 September 2017

language of work or name

0 references

publication date

5 July 2009

1 reference

Europe PubMed Central

14 September 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

14 September 2017

17

1 reference

Europe PubMed Central

14 September 2017

17

1 reference

Europe PubMed Central

14 September 2017

6463-6480

1 reference

Europe PubMed Central

14 September 2017

An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Excitotoxic neuronal death and the pathogenesis of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

1 reference

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22 September 2017

Memantine: a review of its use in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Glutamate-based therapeutic approaches: NR2B receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Glutamate receptor gating.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Acquired QT interval prolongation and HERG: implications for drug discovery and development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Rationale for and use of NMDA receptor antagonists in Parkinson's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Structure and function of glutamate receptor ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

NR2B selective NMDA receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Pathobiology of ischaemic stroke: an integrated view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Antagonists selective for NMDA receptors containing the NR2B subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

The glutamate receptor ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

The role of neuronal energy in the neurotoxicity of excitatory amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

22 September 2017

Current concepts of excitotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

25 September 2017

Molecular mechanisms of trauma-induced neuronal degeneration

1 reference

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25 September 2017

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

The novel N-methyl-D-aspartate (NMDA) antagonist CGS 19755 prevents ischemia-induced reductions of adenosine A1, NMDA, and PCP receptors in gerbil brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

17 June 2018

Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.

1 reference

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20 August 2018

Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles

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20 August 2018

Oxamides as novel NR2B selective NMDA receptor antagonists

1 reference

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20 August 2018

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

20 August 2018

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists

1 reference

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20 August 2018

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

20 August 2018

Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-D-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease.

1 reference

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20 August 2018

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.

1 reference

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20 August 2018

A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891242

20 August 2018

Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats.

1 reference

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20 August 2018

In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.

1 reference

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20 August 2018

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19648014

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19648014

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19648014

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2009.05.085

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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