(Q39819746)

English

Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

head and neck squamous cell carcinoma

0 references

1 reference

based on heuristic

inferred from title

3

object named as

Malabika Sen

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Jennifer Rubin Grandis

6

object named as

Jennifer R Grandis

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

2

object named as

Yan Zang

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Rebecca J Leeman-Neill

4

object named as

Rebecca J Leeman-Neill

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

author name string

Changyou Li

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

David S K Man

5

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Daniel E Johnson

7

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

publication date

28 July 2009

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

2211-2220

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells.

1 reference

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Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.

1 reference

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22 September 2017

Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells

1 reference

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Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.

1 reference

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Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.

1 reference

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Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells

1 reference

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Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice

1 reference

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Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase

1 reference

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Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation

1 reference

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Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

1 reference

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

1 reference

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Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.

1 reference

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Cancer statistics, 2007

1 reference

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22 September 2017

Bortezomib inhibits cell-cell adhesion and cell migration and enhances epidermal growth factor receptor inhibitor-induced cell death in squamous cell cancer

1 reference

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22 September 2017

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

1 reference

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Reassessment of the role of induction chemotherapy for head and neck cancer

1 reference

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Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

1 reference

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An oligonucleotide decoy for Stat3 activates the immune response of macrophages to breast cancer

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Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

1 reference

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Bortezomib: proteasome inhibition as an effective anticancer therapy

1 reference

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Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma

1 reference

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22 September 2017

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.

1 reference

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Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

1 reference

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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768047

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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768047

22 September 2017

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768047

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2768047

22 September 2017

STAT signaling in head and neck cancer

1 reference

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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

1 reference

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Stat3 as an oncogene

1 reference

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

1 reference

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Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival

1 reference

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma.

1 reference

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Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer

1 reference

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Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor

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Expression of Bcl-2 family proteins in advanced laryngeal squamous cell carcinoma: correlation with response to chemotherapy and organ preservation

1 reference

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Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma

1 reference

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Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma

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In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

1 reference

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Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma

1 reference

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Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

1 reference

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Epidermal growth factor receptor--mediated stat3 signaling blocks apoptosis in head and neck cancer

1 reference

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A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unraveling MCL-1 degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19638453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-09-0327

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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