(Q39876253)

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Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: Implication for future drug discovery and development for AD

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: Implication for future drug discovery and development for AD (English)

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Alzheimer's disease

0 references

translational medicine

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Hong I Wan

1

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

J Steve Jacobsen

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

J Lynn Rutkowski

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Giora Z Feuerstein

4

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

language of work or name

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publication date

1 June 2009

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Europe PubMed Central

PMC publication ID

15 September 2017

Clinical and Translational Science

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Europe PubMed Central

PMC publication ID

15 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

242-247

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

1 reference

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Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

1 reference

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Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

1 reference

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Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

1 reference

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Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

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Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

1 reference

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

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22 September 2017

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

1 reference

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22 September 2017

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

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22 September 2017

Selective inhibition of Abeta42 production by NSAID R-enantiomers

1 reference

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Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies

1 reference

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

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Alzheimer's disease: genes, proteins, and therapy

1 reference

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Rates of hippocampal atrophy correlate with change in clinical status in aging and AD.

1 reference

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

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22 September 2017

Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging.

1 reference

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20 August 2018

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

1 reference

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20 August 2018

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

1 reference

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20 August 2018

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

1 reference

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20 August 2018

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

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20 August 2018

Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis.

1 reference

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20 August 2018

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5350742

20 August 2018

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5350742

20 August 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5350742

20 August 2018

Identifiers

10.1111/J.1752-8062.2009.00121.X

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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