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English
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.
scientific article published on January 2008
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
title
Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
author
Thomas Kukar
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
author name string
Todd E Golde
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
publication date
1 January 2008
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
published in
Current Topics in Medicinal Chemistry
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
volume
8
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
page(s)
47-53
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
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Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease
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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.
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Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review
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Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease
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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
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Anti-inflammatory therapy in Alzheimer's disease: is hope still alive?
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Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity
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Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's disease
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6 September 2017
Selective inhibition of Abeta42 production by NSAID R-enantiomers
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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Deciphering the genetic basis of Alzheimer's disease
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Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation
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6 September 2017
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
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6 September 2017
Inflammation and Alzheimer's disease
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6 September 2017
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors
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6 September 2017
Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice
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6 September 2017
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
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6 September 2017
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene
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6 September 2017
Secretion of the Notch-1 Abeta-like peptide during Notch signaling
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14 September 2017
Nimodipine selectively stimulates beta-amyloid 1-42 secretion by a mechanism independent of calcium influx blockage.
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14 September 2017
Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho
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Cyclooxygenase (COX)-2 and COX-1 Potentiate β-Amyloid Peptide Generation through Mechanisms That Involve γ-Secretase Activity
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14 September 2017
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production
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26 June 2018
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
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26 June 2018
The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent
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2 September 2018
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
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PubMed Central
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2 September 2018
Can NSAIDs contribute to Alzheimer's disease?
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
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2 September 2018
Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
retrieved
2 September 2018
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
retrieved
2 September 2018
Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures
1 reference
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PubMed Central
reference URL
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2 September 2018
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial
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PubMed Central
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2 September 2018
Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
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2 September 2018
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
1 reference
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PubMed Central
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2 September 2018
Double placebo design in a prevention trial for Alzheimer's disease.
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2 September 2018
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740624
retrieved
2 September 2018
Diagnosis and treatment of Alzheimer's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18220932
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transgenic mouse models of Alzheimer's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18220932
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2174/156802608783334042
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
PMCID
2740624
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
PubMed ID
18220932
1 reference
stated in
Europe PubMed Central
PMCID
2740624
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18220932%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 January 2020
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