(Q39889775)

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Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer

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scholarly article

1 reference

Europe PubMed Central

15 September 2017

Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer (English)

1 reference

Europe PubMed Central

15 September 2017

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1 reference

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inferred from title

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Helmut Friess

1 reference

Europe PubMed Central

15 September 2017

author name string

Peter Büchler

1

1 reference

Europe PubMed Central

15 September 2017

Howard A Reber

2

1 reference

Europe PubMed Central

15 September 2017

James S Tomlinson

3

1 reference

Europe PubMed Central

15 September 2017

Oliver Hankinson

4

1 reference

Europe PubMed Central

15 September 2017

Georgis Kallifatidis

5

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Europe PubMed Central

15 September 2017

Ingrid Herr

7

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Europe PubMed Central

15 September 2017

Oscar J Hines

8

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Europe PubMed Central

15 September 2017

publication date

1 February 2009

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Europe PubMed Central

15 September 2017

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Europe PubMed Central

15 September 2017

11

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Europe PubMed Central

15 September 2017

2

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Europe PubMed Central

15 September 2017

196-206

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Europe PubMed Central

15 September 2017

Regulation of the Warburg effect in early-passage breast cancer cells.

1 reference

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22 September 2017

High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Prostate cancer cell-derived urokinase-type plasminogen activator contributes to intraosseous tumor growth and bone turnover.

1 reference

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22 September 2017

Hypoxia in cancer: significance and impact on clinical outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

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HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Hypoxia inhibits paclitaxel-induced apoptosis through adenosine-mediated phosphorylation of bad in glioblastoma cells

1 reference

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Target therapy using a small molecule inhibitor against angiogenic receptors in pancreatic cancer

1 reference

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The role of the hypoxia-inducible factor in tumor metabolism growth and invasion.

1 reference

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22 September 2017

Hypoxia signalling in cancer and approaches to enforce tumour regression

1 reference

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22 September 2017

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

1 reference

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22 September 2017

Role of lymphangiogenesis and lymphangiogenic factors during pancreatic cancer progression and lymphatic spread

2 references

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22 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

20 August 2018

uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Integration of oxygen signaling at the consensus HRE.

1 reference

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22 September 2017

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

HIF hydroxylation and cellular oxygen sensing

1 reference

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22 September 2017

Tumor Oxygen Dynamics: Correlation of In Vivo MRI with Histological Findings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Targeting HIF-1 for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

uPAR: a versatile signalling orchestrator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

'The metabolism of tumours': 70 years later

1 reference

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22 September 2017

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Causes and effects of heterogeneous perfusion in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Genetic progression and divergence in pancreatic carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Genetic progression in the pancreatic ducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Integrin signaling

1 reference

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22 September 2017

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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22 September 2017

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase

1 reference

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22 September 2017

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

22 September 2017

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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22 September 2017

A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631144

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

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22 September 2017

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes

1 reference

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Tumor hypoxia, drug resistance, and metastases

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

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22 September 2017

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

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22 September 2017

Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1.

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25 September 2017

Regulation of integrin function by the urokinase receptor

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25 September 2017

Candidate genes for the hypoxic tumor phenotype.

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15 June 2018

The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation.

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15 June 2018

Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay.

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15 June 2018

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

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15 June 2018

Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression

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20 August 2018

The hypoxic response of tumors is dependent on their microenvironment.

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20 August 2018

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

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20 August 2018

Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

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20 August 2018

Transcriptional response to hypoxia in human tumors

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20 August 2018

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia.

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20 August 2018

Tumor cell intravasation alu-cidated: the chick embryo opens the window

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https://pubmed.ncbi.nlm.nih.gov/19177204

12 December 2020

based on heuristic

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Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19177204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19177204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19177204

12 December 2020

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Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19177204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1593/NEO.08734

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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