(Q39890460)

15 September 2017

title

The preclinical activity of the histone deacetylase inhibitor PXD101 (belinostat) in hepatocellular carcinoma cell lines (English)

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ORCID Public Data File 2021

15 September 2017

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author name string

Brigette B Y Ma

1

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15 September 2017

Fion Sung

2

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15 September 2017

Qian Tao

3

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15 September 2017

Fan Fong Poon

4

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15 September 2017

Vivian W Lui

5

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15 September 2017

Winnie Yeo

6

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15 September 2017

Stephen L Chan

7

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15 September 2017

Anthony T C Chan

8

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15 September 2017

publication date

27 January 2009

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Investigational New Drugs

15 September 2017

published in

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15 September 2017

volume

28

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15 September 2017

issue

2

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15 September 2017

page(s)

107-114

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Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

15 September 2017

cites work

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12 December 2020

Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein

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12 December 2020

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

1 reference

12 December 2020

Frequent down-regulation of E-cadherin by genetic and epigenetic changes in the malignant progression of hepatocellular carcinomas

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12 December 2020

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

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12 December 2020

Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.

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12 December 2020

Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation

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12 December 2020

Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9

1 reference

12 December 2020

Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells.

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12 December 2020

CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines

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12 December 2020

The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells

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12 December 2020

Primary liver cancer: worldwide incidence and trends

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12 December 2020

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

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12 December 2020

The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo.

1 reference

12 December 2020

Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma

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12 December 2020

Promoter hypermethylation of the cyclin-dependent kinase inhibitor (CDKI) gene p21WAF1/CIP1/SDI1 is rare in various lymphomas and carcinomas

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12 December 2020

Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma

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12 December 2020

Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors

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12 December 2020

Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma.

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12 December 2020

HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

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12 December 2020

SFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathway

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12 December 2020

Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas

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12 December 2020

Detection of hepatitis B virus DNA in hepatocellular carcinoma: methylation of integrated viral DNA.

1 reference

12 December 2020

Genetics of hepatocellular tumors.

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12 December 2020

Distinctive gene expression profiles associated with Hepatitis B virus x protein

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12 December 2020

Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

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12 December 2020

Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma

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12 December 2020

Gene expression associated with the decrease in malignant phenotype of human liver cancer cells following stimulation with a histone deacetylase inhibitor.

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12 December 2020

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

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12 December 2020

ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11

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12 December 2020

Review of genetic and epigenetic alterations in hepatocarcinogenesis

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12 December 2020

Enhancement of hepatitis-B surface-antigen expression by 5-azacytidine in a hepatitis-B-virus-transfected cell line

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12 December 2020

Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells

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12 December 2020

Cell growth inhibition and gene expression induced by the histone deacetylase inhibitor, trichostatin A, on human hepatoma cells

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12 December 2020

Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands.

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12 December 2020

10.1007/S10637-009-9219-7

Identifiers

DOI

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15 September 2017

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