(Q39922552)

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Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations

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scholarly article

1 reference

Europe PubMed Central

15 September 2017

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations (English)

1 reference

Europe PubMed Central

15 September 2017

hypermethylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

15 September 2017

7

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Europe PubMed Central

15 September 2017

8

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Europe PubMed Central

15 September 2017

9

object named as

Ian P M Tomlinson

1 reference

Europe PubMed Central

15 September 2017

author name string

Stefania Segditsas

1

1 reference

Europe PubMed Central

15 September 2017

Andrew Rowan

3

1 reference

Europe PubMed Central

15 September 2017

Fernando Setien

4

1 reference

Europe PubMed Central

15 September 2017

Kay Neale

5

1 reference

Europe PubMed Central

15 September 2017

Robin K S Phillips

6

1 reference

Europe PubMed Central

15 September 2017

publication date

11 October 2008

1 reference

Europe PubMed Central

15 September 2017

Experimental and Molecular Pathology

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Europe PubMed Central

15 September 2017

85

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Europe PubMed Central

15 September 2017

3

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Europe PubMed Central

15 September 2017

201-206

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Europe PubMed Central

15 September 2017

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Multiple forms of the APC gene transcripts and their tissue-specific expression.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Refining Molecular Analysis in the Pathways of Colorectal Carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

APC and the three-hit hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

CpG island methylation is a common finding in colorectal cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXMP.2008.09.006

7 January 2021

Identifiers

10.1016/J.YEXMP.2008.09.006

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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