(Q39932292)

15 September 2017

APC and the three-hit hypothesis (English)

1 reference

15 September 2017

12

1 reference

15 September 2017

11

E J Sawyer

1 reference

15 September 2017

13

I P M Tomlinson

1 reference

15 September 2017

S Segditsas

1

1 reference

15 September 2017

A J Rowan

2

1 reference

15 September 2017

K Howarth

3

1 reference

15 September 2017

A Jones

4

1 reference

15 September 2017

S Leedham

5

1 reference

15 September 2017

N A Wright

6

1 reference

15 September 2017

P Gorman

7

1 reference

15 September 2017

W Chambers

8

1 reference

15 September 2017

E Domingo

9

1 reference

15 September 2017

R R Roylance

10

1 reference

15 September 2017

language of work or name

English

0 references

publication date

6 October 2008

1 reference

15 September 2017

1 reference

15 September 2017

28

1 reference

15 September 2017

146-155

1 reference

15 September 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2008.361

15 September 2017

0 references

cites work

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Disease model: familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Two genetic hits (more or less) to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Can chromosomal instability initiate tumorigenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Tissue, cell and stage specificity of (epi)mutations in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.361

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.361

1 reference

Dimensions Publication ID

15 September 2017

0 references

1 reference