(Q39930727)

15 September 2017

title

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression (English)

1 reference

alternative mRNA splicing, via spliceosome

15 September 2017

main subject

1 reference

Yoshiro Chuman

1

1 reference

15 September 2017

Wataru Kurihashi

2

1 reference

15 September 2017

Yohei Mizukami

3

1 reference

15 September 2017

Takehiro Nashimoto

4

1 reference

15 September 2017

Hiroaki Yagi

5

1 reference

15 September 2017

Kazuyasu Sakaguchi

6

1 reference

15 September 2017

language of work or name

1 reference

9 October 2008

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15 September 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Journal of Biochemistry

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15 September 2017

volume

145

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15 September 2017

issue

1

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15 September 2017

page(s)

1-12

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

15 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The 17q23 amplicon and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Frequent alternative splicing of human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The connection between splicing and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Global analysis of mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Mutational analysis of the domain structure of mouse protein phosphatase 2Cbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

A minor alternative transcript of the fumarylacetoacetate hydrolase gene produces a protein despite being likely subjected to nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Heregulins implicated in cellular functions other than receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJB%2FMVN135

21 January 2018

Identifiers

DOI

10.1093/JB/MVN135

1 reference

15 September 2017

1 reference