(Q48022280)

English

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.

scientific article published on 29 February 2004

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scholarly article

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. (English)

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Albert J Fornace

8

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Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

author name string

Dmitry V Bulavin

1

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Crissy Phillips

2

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Bonnie Nannenga

3

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Oleg Timofeev

4

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Larry A Donehower

5

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Carl W Anderson

6

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Ettore Appella

7

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Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

language of work or name

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publication date

29 February 2004

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

Nature Genetics

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Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

36

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Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

4

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7 February 2018

http://europepmc.org/abstract/MED/14991053

343-350

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Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

https://scigraph.springernature.com/pub.10.1038/ng1317

0 references

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Mechanism of p38 MAP kinase activation in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

p16(MTS-1/CDKN2/INK4a) in cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Genetic alterations in breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Cyclin D1 protein expression and function in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

21 January 2018

Methylation of the p16(Ink4a) tumor suppressor gene 5'-CpG island in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

7 January 2021

based on heuristic

inferred from DOI database lookup

Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after gamma-irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

7 January 2021

based on heuristic

inferred from DOI database lookup

Estimation of relative mRNA content by filter hybridization to a polyuridylic probe

1 reference

https://api.crossref.org/works/10.1038%2FNG1317

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

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release_qwg65e4hqjfvphlycwvkzq2zlu

0 references

1 reference

Europe PubMed Central

7 February 2018

http://europepmc.org/abstract/MED/14991053

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