(Q39945377)

15 September 2017

Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity (English)

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15 September 2017

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7

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15 September 2017

Sandra Verstraelen

1

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15 September 2017

Bernard Peers

2

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15 September 2017

Walid Maho

3

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15 September 2017

Karen Hollanders

4

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15 September 2017

Sylvie Remy

5

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15 September 2017

Pascale Berckmans

6

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15 September 2017

Hilda Witters

8

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15 September 2017

language of work or name

English

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publication date

4 March 2016

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Journal of Applied Toxicology

15 September 2017

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15 September 2017

36

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15 September 2017

9

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15 September 2017

1194-1206

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Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.

15 September 2017

1 reference

A toxicologist's guide to biomarkers of hepatic response

21 January 2018

1 reference

Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.

21 January 2018

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A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States

21 January 2018

1 reference

Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems

21 January 2018

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New school in liver development: lessons from zebrafish

21 January 2018

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Mechanistic classification of liver injury

21 January 2018

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The biology of transferrin

21 January 2018

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Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.

21 January 2018

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Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

21 January 2018

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A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

21 January 2018

1 reference

Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study

21 January 2018

1 reference

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

21 January 2018

1 reference

Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals.

21 January 2018

1 reference

Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides.

21 January 2018

1 reference

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

21 January 2018

1 reference

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

21 January 2018

1 reference

Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay - progress report on phase I.

21 January 2018

1 reference

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans

21 January 2018

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Transcriptional suppression of the transferrin gene by hypolipidemic peroxisome proliferators

21 January 2018

1 reference

Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

21 January 2018

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The zebrafish reference genome sequence and its relationship to the human genome

21 January 2018

1 reference

The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development

21 January 2018

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Mechanisms of hepatotoxicity

21 January 2018

1 reference

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

21 January 2018

1 reference

Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster

21 January 2018

1 reference

Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses

21 January 2018

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Organotypic liver culture models: meeting current challenges in toxicity testing

21 January 2018

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Drug-induced hepatotoxicity.

21 January 2018

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Diminished serum Gc (vitamin D-binding protein) levels and increased Gc:G-actin complexes in a hamster model of fulminant hepatic necrosis

21 January 2018

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sox4b is a key player of pancreatic alpha cell differentiation in zebrafish

21 January 2018

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The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

21 January 2018

1 reference

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

21 January 2018

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Liver fatty acid-binding protein: an early and sensitive plasma marker of hepatocellular damage and a reliable predictor of graft viability after liver transplantation from non-heart-beating donors.

21 January 2018

1 reference

Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: liver, intestine, and exocrine pancreas

21 January 2018

1 reference

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

21 January 2018

1 reference

Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation

21 January 2018

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High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

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High-throughput in vivo vertebrate screening

21 January 2018

1 reference

Emerging roles of caspase-3 in apoptosis

21 January 2018

1 reference

Temporal profile of total, bound, and free Gc-globulin after acetaminophen overdose

21 January 2018

1 reference

Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish

21 January 2018

1 reference

Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva

21 January 2018

1 reference

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans

21 January 2018

1 reference

Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?

21 January 2018

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Zebrafish as model organisms for studying drug-induced liver injury

21 January 2018

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Uptake, toxicity, and effects on detoxication enzymes of atrazine and trifluoroacetate in embryos of zebrafish.

21 January 2018

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Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JAT.3288

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15 September 2017

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