(Q39964292)

15 September 2017

Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors (English)

1 reference

15 September 2017

Jeffrey D Winkler

1

1 reference

15 September 2017

André K Isaacs

2

1 reference

15 September 2017

Chaomei Xiang

3

1 reference

15 September 2017

Valérie Baubet

4

1 reference

15 September 2017

Nadia Dahmane

5

1 reference

15 September 2017

1 December 2011

1 reference

15 September 2017

1 reference

15 September 2017

67

1 reference

15 September 2017

52

1 reference

15 September 2017

10261-10266

1 reference

Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network

15 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Communicating with Hedgehogs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Activation of the hedgehog pathway in advanced prostate cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Small molecule modulation of Smoothened activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Hedgehog signaling in animal development: paradigms and principles

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Companies race to develop first Hedgehog inhibitor cancer drug

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Veratramine-induced behavior associated with serotonergic hyperfunction in mice

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Genentech obtains proof of concept for hedgehog inhibition.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Medulloblastoma growth inhibition by hedgehog pathway blockade

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Teratogen-mediated inhibition of target tissue response to Shh signaling

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3244726

Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine

20 August 2018

1 reference

12 December 2020

Frequent requirement of hedgehog signaling in non-small cell lung carcinoma

1 reference

12 December 2020

Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

1 reference

12 December 2020

Teratogenic compounds of Veratrum californicum (Durand). II. Production of ovine fetal cyclopia by fractions and alkaloid preparations

1 reference

12 December 2020

Teratogenic compounds inVeratrum californicum (Durand). IX. Structure-activity relation

1 reference

12 December 2020

Effects of teratogenic agents in range plants

1 reference

12 December 2020

Pharmacological tests of the mechanism of the periodic rhythm caused by veratramine in the sinoatrial node of the guinea pig

1 reference

12 December 2020

10.1016/J.TET.2011.10.028

Identifiers

DOI

1 reference

15 September 2017

1 reference

15 September 2017

PubMed publication ID

22199406

1 reference