(Q39967268)

16 September 2017

title

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers (English)

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16 September 2017

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Nicolas Dzamko

1

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Dominic B Rowe

object named as

Dominic B Rowe

series ordinal

2

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Glenda Halliday

object named as

Glenda M Halliday

series ordinal

3

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language of work or name

English

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publication date

25 February 2016

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16 September 2017

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16 September 2017

volume

31

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16 September 2017

issue

6

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16 September 2017

page(s)

889-897

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

16 September 2017

cites work

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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LRRK2 gene variation and its contribution to Parkinson disease

21 January 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

1 reference

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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1 reference

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).

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Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinic

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Inflammation is genetically implicated in Parkinson's disease.

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The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

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LRRK2 inhibition attenuates microglial inflammatory responses

21 January 2018

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

21 January 2018

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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

21 January 2018

1 reference

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders

21 January 2018

1 reference

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

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1 reference

An inflammatory review of Parkinson's disease.

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Inflammation and neurodegeneration in Parkinson's disease

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Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

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Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism

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Neuroinflammation in Parkinson's disease.

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Cerebrospinal fluid inflammatory markers in Parkinson's disease--associations with depression, fatigue, and cognitive impairment.

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The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse

21 January 2018

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Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

21 January 2018

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A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice

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Role of inflammation in gastrointestinal tract in aetiology and pathogenesis of idiopathic parkinsonism

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Parkinson's disease: a dual-hit hypothesis

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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

21 January 2018

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Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

21 January 2018

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Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra

21 January 2018

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Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

21 January 2018

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Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

21 January 2018

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Peripheral cytokines profile in Parkinson's disease.

21 January 2018

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Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism

21 January 2018

1 reference

Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum

21 January 2018

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Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease.

21 January 2018

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Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

21 January 2018

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Colonic inflammation in Parkinson's disease.

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Premotor and nonmotor features of Parkinson's disease

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Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders

21 January 2018

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Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

1 reference

Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

21 January 2018

1 reference

LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance.

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5.

21 January 2018

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

21 January 2018

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Short- and long-term effects of LRRK2 on axon and dendrite growth

21 January 2018

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Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling

21 January 2018

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Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients

21 January 2018

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Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease

21 January 2018

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Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations.

21 January 2018

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Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease.

21 January 2018

1 reference

Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease

21 January 2018

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Cytokines in CSF correlate with HIV-associated neurocognitive disorders in the post-HAART era in China.

21 January 2018

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Serum levels of interleukin-6 are elevated in patients with Parkinson's disease and correlate with physical performance

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MDS.26529

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16 September 2017

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