Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q39970262)
Watch
English
Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.
scientific article
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
title
Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
author
Scott E Boyken
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
Amy H. Andreotti
series ordinal
3
object named as
Amy H Andreotti
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
author name string
D Bruce Fulton
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
publication date
16 July 2012
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
published in
Protein Science
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
volume
21
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
issue
9
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
page(s)
1288-1297
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
cites work
NMR View: A computer program for the visualization and analysis of NMR data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Itk: the rheostat of the T cell response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Identification of an allosteric signaling network within Tec family kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Diverse somatic mutation patterns and pathway alterations in human cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
T-cell signaling regulated by the Tec family kinase, Itk.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
I-TASSER: a unified platform for automated protein structure and function prediction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Disrupting the intermolecular self-association of Itk enhances T cell signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
SH2-dependent autophosphorylation within the Tec family kinase Itk.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Conformational snapshots of Tec kinases during signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
A remote substrate docking mechanism for the tec family tyrosine kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Pleckstrin homology (PH) domains and phosphoinositides
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
TEC-family kinases: regulators of T-helper-cell differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Tec family kinases in T lymphocyte development and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Mars -- robust automatic backbone assignment of proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Ligand specificity modulated by prolyl imide bond Cis/Trans isomerization in the Itk SH2 domain: a quantitative NMR study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
A specific intermolecular association between the regulatory domains of a Tec family kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
The PH superfold: a structural scaffold for multiple functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
NMRPipe: a multidimensional spectral processing system based on UNIX pipes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Amino acid preferences for specific locations at the ends of alpha helices
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Helix signals in proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
22 September 2017
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
25 September 2017
Pleckstrin homology domains interact with filamentous actin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
17 June 2018
Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
17 June 2018
Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
20 August 2018
Heteronuclear relaxation study of the PH domain of beta-spectrin: restriction of loop motions upon binding inositol trisphosphate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
20 August 2018
Dissecting alpha-helices: position-specific analysis of alpha-helices in globular proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631358
retrieved
20 August 2018
Binding of G protein beta gamma-subunits to pleckstrin homology domains
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22761113
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22761113
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Positive regulation of Itk PH domain function by soluble IP4
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22761113
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1002/PRO.2114
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
PMC publication ID
3631358
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
PubMed publication ID
22761113
1 reference
stated in
Europe PubMed Central
PMC publication ID
3631358
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761113%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 February 2020
ResearchGate publication ID
228115876
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
