(Q39978313)

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How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha

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scholarly article

1 reference

Europe PubMed Central

16 September 2017

How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha (English)

1 reference

Europe PubMed Central

16 September 2017

molecular chaperones

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4

object named as

Ralf Paus

1 reference

Europe PubMed Central

16 September 2017

Silvia Bulfone-Paus

5

object named as

Silvia Bulfone-Paus

1 reference

Europe PubMed Central

16 September 2017

Erwin H Duitman

1

object named as

Erwin H Duitman

1 reference

Europe PubMed Central

16 September 2017

3

object named as

Elena Bulanova

1 reference

Europe PubMed Central

16 September 2017

author name string

Zane Orinska

2

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Europe PubMed Central

16 September 2017

language of work or name

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publication date

27 May 2008

1 reference

Europe PubMed Central

16 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

16 September 2017

28

1 reference

Europe PubMed Central

16 September 2017

15

1 reference

Europe PubMed Central

16 September 2017

4851-4861

1 reference

Europe PubMed Central

16 September 2017

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation

1 reference

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22 September 2017

Regulated exocytosis: merging ideas on fusing membranes.

1 reference

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22 September 2017

Dendritic cells prime natural killer cells by trans-presenting interleukin 15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

IL-15/IL-15 receptor biology: a guided tour through an expanding universe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion.

1 reference

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22 September 2017

Human natural killer cell development and biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

RETRACTED: A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

A role for the phagosome in cytokine secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

A novel autoregulatory mechanism for transcriptional activation of the IL-15 gene by a nonsecretable isoform of IL-15 generated by alternative splicing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Hematopoietic secretory granules as vehicles for the local delivery of cytokines and soluble cytokine receptors at sites of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Synthesis and secretion of interleukin-15 by freshly isolated human bronchial epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Reverse signaling through membrane-bound interleukin-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Constitutive protein secretion from the trans-Golgi network to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Mast Cells Express Novel Functional IL-15 Receptor α Isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Intracellular localization of the p35 subunit of murine IL-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Oligosaccharyl transferase: gatekeeper to the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The IL-15R alpha chain signals through association with Syk in human B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

1 reference

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22 September 2017

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1 reference

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Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

1 reference

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22 September 2017

Constitutive and regulated secretion of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

22 September 2017

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

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Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

17 June 2018

The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

17 June 2018

Coordination between enzyme specificity and intracellular compartmentation in the control of protein-bound oligosaccharide biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

17 June 2018

IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

T cells use two directionally distinct pathways for cytokine secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis?

1 reference

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20 August 2018

Interleukin-15 protects from lethal apoptosis in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

A flow cytometric and immunofluorescence microscopic study of tumor necrosis factor production and localization in human monocytes

1 reference

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20 August 2018

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493373

20 August 2018

The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of the interleukin-15 alpha receptor and its implications for ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER targeting signals: more than meets the eye?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 15 production by macrophages in the implant interface membrane of aseptically loosened joint replacements

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of glycosylated human interleukin-2 by recombinant mammalian cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/18505820

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

1 reference

18 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1182/BLOOD.V93.10.3531.410K32_3531_3539

Identifiers

10.1128/MCB.02178-07

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

1 reference

Europe PubMed Central

16 September 2017

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