(Q40007756)

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Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression

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scholarly article

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Europe PubMed Central

PubMed publication ID

16 September 2017

Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

prostate cancer

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inferred from title

object named as

John D Hooper

7

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Hemamali Samaratunga

object named as

Hemamali Samaratunga

5

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Judith Clements

object named as

Judith A Clements

6

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author name string

Andrew J Ramsay

1

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Ying Dong

2

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Melanie L Hunt

3

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Europe PubMed Central

PubMed publication ID

16 September 2017

MayLa Linn

4

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Europe PubMed Central

PubMed publication ID

16 September 2017

language of work or name

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publication date

28 February 2008

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Europe PubMed Central

PubMed publication ID

16 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

16 September 2017

283

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Europe PubMed Central

PubMed publication ID

16 September 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

12293-12304

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Compartmentalized expression of kallikrein 4 (KLK4/hK4) isoforms in prostate cancer: nuclear, cytoplasmic and secreted forms.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

How the protease thrombin talks to cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Protease-activated receptors: contribution to physiology and disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Proteinase-activated receptors, targets for kallikrein signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Determination of the operational molarity of solutions of bovine α-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

On the art of identifying effective and specific siRNAs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

PAR3 is a cofactor for PAR4 activation by thrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Molecular cloning of a potential proteinase activated receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

A dual thrombin receptor system for platelet activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Cloning and characterization of human protease-activated receptor 4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Isolation of a human prostate carcinoma cell line (DU 145)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Prostate cancer: a dynamic illness with shifting targets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Expression of protease-activated receptor-2 by osteoblasts.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Rho proteins in cell migration and metastasis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Biology and clinical management of prostate cancer bone metastasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Thrombin receptor expression is upregulated in prostate cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Expression of the thrombin receptor in developing bone and associated tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Zinc concentration in human prostatic fluid: normal, chronic prostatitis, adenoma and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

The coagulation cascade: initiation, maintenance, and regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Calcium signalling: dynamics, homeostasis and remodelling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Mitogenic signaling pathways induced by G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709493200

21 January 2018

Identifiers

10.1074/JBC.M709493200

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 September 2017

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