(Q40016575)

16 September 2017

title

Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1. (English)

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16 September 2017

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6

Shunsuke Aoki

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16 September 2017

Tomohiro Kabuta

1

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16 September 2017

Rieko Setsuie

2

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16 September 2017

Takeshi Mitsui

3

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16 September 2017

Aiko Kinugawa

4

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16 September 2017

Mikako Sakurai

5

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16 September 2017

Kenko Uchida

7

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16 September 2017

Keiji Wada

8

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16 September 2017

language of work or name

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4 February 2008

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16 September 2017

published in

Human Molecular Genetics

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16 September 2017

volume

17

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16 September 2017

issue

10

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16 September 2017

page(s)

1482-1496

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The ubiquitin pathway in Parkinson's disease

16 September 2017

cites work

1 reference

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Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

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UCHL1 is a Parkinson's disease susceptibility gene

21 January 2018

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UCHL-1 is not a Parkinson's disease susceptibility gene

21 January 2018

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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

21 January 2018

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Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

21 January 2018

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

21 January 2018

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Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

21 January 2018

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Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

21 January 2018

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Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

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Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

21 January 2018

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Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

21 January 2018

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

21 January 2018

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Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

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Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

21 January 2018

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

21 January 2018

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Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex

21 January 2018

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Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

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Role of reactive aldehyde in cardiovascular diseases

21 January 2018

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Histidine and lysine as targets of oxidative modification

21 January 2018

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Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions

21 January 2018

1 reference

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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

21 January 2018

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Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

21 January 2018

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Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1

21 January 2018

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Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

21 January 2018

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Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

21 January 2018

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21 January 2018

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Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease

21 January 2018

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Stabilization of hyperdynamic microtubules is neuroprotective in amyotrophic lateral sclerosis

21 January 2018

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The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

21 January 2018

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Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

21 January 2018

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

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Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

21 January 2018

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

21 January 2018

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Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene

21 January 2018

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Proteasomal dysfunction: a common feature of neurodegenerative diseases? Implications for the environmental origins of neurodegeneration

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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pEF-BOS, a powerful mammalian expression vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN037

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN037

Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN037

Differential utilization of beta-tubulin isotypes in differentiating neurites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN037

21 January 2018

Identifiers

DOI

10.1093/HMG/DDN037

1 reference

release_bwzdrkjxdvh7njvo4vggzwet6a

16 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bwzdrkjxdvh7njvo4vggzwet6a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference