(Q40030648)

16 September 2017

The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral (English)

1 reference

16 September 2017

anti-retroviral agent

0 references

author name string

Edward P Garvey

1

1 reference

16 September 2017

Brian A Johns

2

1 reference

16 September 2017

Margaret J Gartland

3

1 reference

16 September 2017

Scott A Foster

4

1 reference

16 September 2017

Wayne H Miller

5

1 reference

16 September 2017

Robert G Ferris

6

1 reference

16 September 2017

Richard J Hazen

7

1 reference

16 September 2017

Mark R Underwood

8

1 reference

16 September 2017

Eric E Boros

9

1 reference

16 September 2017

James B Thompson

10

1 reference

16 September 2017

Jason G Weatherhead

11

1 reference

16 September 2017

Cecilia S Koble

12

1 reference

16 September 2017

Scott H Allen

13

1 reference

16 September 2017

Lee T Schaller

14

1 reference

16 September 2017

Ronald G Sherrill

15

1 reference

16 September 2017

Tomokazu Yoshinaga

16

1 reference

16 September 2017

Masanori Kobayashi

17

1 reference

16 September 2017

Chiaki Wakasa-Morimoto

18

1 reference

16 September 2017

Shigeru Miki

19

1 reference

16 September 2017

Koichiro Nakahara

20

1 reference

16 September 2017

Takeshi Noshi

21

1 reference

16 September 2017

Akihiko Sato

22

1 reference

16 September 2017

Tamio Fujiwara

23

1 reference

16 September 2017

language of work or name

English

0 references

publication date

26 December 2007

1 reference

Antimicrobial Agents and Chemotherapy

16 September 2017

1 reference

16 September 2017

52

1 reference

16 September 2017

3

1 reference

16 September 2017

901-908

1 reference

In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV

16 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Design of second generation HIV-1 integrase inhibitors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Analysis of early human immunodeficiency virus type 1 DNA synthesis by use of a new sensitive assay for quantifying integrated provirus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

S-1360 Shionogi-GlaxoSmithKline.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Interactions of 1263W94 with other antiviral agents in inhibition of human cytomegalovirus replication.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Phenotypic analysis of the sensitivity of HIV-1 to inhibitors of the reverse transcriptase, protease, and integrase using a self-inactivating virus vector system

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

A quantitative assay for HIV DNA integration in vivo

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Small amino acid changes in the V3 loop of human immunodeficiency virus type 2 determines the coreceptor usage for CXCR4 and CCR5.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2258521

Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients

20 August 2018

1 reference

12 December 2020

A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors

1 reference

12 December 2020

A platform for designing HIV integrase inhibitors. Part 1: 2-hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores

1 reference

12 December 2020

Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals

1 reference

12 December 2020

A potent and orally active HIV-1 integrase inhibitor

1 reference

12 December 2020

Raltegravir: a new antiretroviral class for salvage therapy

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.01218-07

1 reference

16 September 2017

1 reference

16 September 2017

PubMed publication ID

18160521

1 reference