(Q40047890)

16 September 2017

title

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases (English)

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16 September 2017

7

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16 September 2017

6

J Keith Joung

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16 September 2017

1

Tatjana I Cornu

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16 September 2017

author name string

Stacey Thibodeau-Beganny

2

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16 September 2017

Eva Guhl

3

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16 September 2017

Stephen Alwin

4

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16 September 2017

Magdalena Eichtinger

5

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16 September 2017

publication date

20 November 2007

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16 September 2017

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16 September 2017

volume

16

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16 September 2017

issue

2

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16 September 2017

page(s)

352-358

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Design and selection of novel Cys2His2 zinc finger proteins

16 September 2017

cites work

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7 January 2021

Drug discovery with engineered zinc-finger proteins

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7 January 2021

Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

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7 January 2021

Gene targeting using zinc finger nucleases

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7 January 2021

Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy

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7 January 2021

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

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7 January 2021

Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

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7 January 2021

Manipulating the mammalian genome by homologous recombination

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7 January 2021

Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae

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7 January 2021

Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells

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7 January 2021

Enhancing Gene Targeting with Designed Zinc Finger Nucleases

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7 January 2021

Chimeric nucleases stimulate gene targeting in human cells

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7 January 2021

Custom zinc-finger nucleases for use in human cells.

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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7 January 2021

High-frequency homologous recombination in plants mediated by zinc-finger nucleases.

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7 January 2021

Efficient gene targeting in Drosophila with zinc-finger nucleases

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7 January 2021

Mammalian gene targeting with designed zinc finger nucleases

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7 January 2021

An improved zinc-finger nuclease architecture for highly specific genome editing

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7 January 2021

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

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7 January 2021

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

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7 January 2021

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

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7 January 2021

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

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7 January 2021

Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

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7 January 2021

Building zinc fingers by selection: toward a therapeutic application

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7 January 2021

A zinc finger directory for high-affinity DNA recognition

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7 January 2021

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

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7 January 2021

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

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7 January 2021

Validated zinc finger protein designs for all 16 GNN DNA triplet targets

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7 January 2021

Scanning the human genome with combinatorial transcription factor libraries.

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7 January 2021

Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

FokI dimerization is required for DNA cleavage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A 2.2 A resolution crystal structure of a designed zinc finger protein bound to DNA

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A genetic screen identifies a cellular regulator of adeno-associated virus.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

High-throughput beta-galactosidase assay for bacterial cell-based reporter systems

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300357

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300357

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16 September 2017

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