(Q40052836)

16 September 2017

Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72 (English)

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12 May 2020

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5

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12 May 2020

Catherine Whibley

6

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12 May 2020

author name string

M Reinbold

1

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12 May 2020

J-L Luo

2

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12 May 2020

T Nedelko

3

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12 May 2020

B Jerchow

4

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12 May 2020

Q Wei

7

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12 May 2020

M Hollstein

8

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12 May 2020

language of work or name

English

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publication date

12 November 2007

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16 September 2017

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12 May 2020

volume

27

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12 May 2020

page(s)

2788-2794

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12 May 2020

issue

19

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210932

12 May 2020

exact match

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cites work

MEF immortalization to investigate the ins and outs of mutagenesis

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12 December 2020

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

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12 December 2020

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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12 December 2020

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

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12 December 2020

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

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12 December 2020

Mutagenesis of human p53 tumor suppressor gene sequences in embryonic fibroblasts of genetically-engineered mice.

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12 December 2020

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers.

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12 December 2020

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

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12 December 2020

The IARC TP53 database: new online mutation analysis and recommendations to users

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12 December 2020

Increased risk of non-small cell lung cancer and frequency of somatic TP53 gene mutations in Pro72 carriers of TP53 Arg72Pro polymorphism.

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12 December 2020

On the origin of G --> T transversions in lung cancer

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12 December 2020

Modelling the molecular circuitry of cancer

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12 December 2020

Two polymorphic variants of wild-type p53 differ biochemically and biologically

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12 December 2020

The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer

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12 December 2020

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

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12 December 2020

Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

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12 December 2020

Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

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12 December 2020

TP53 mutation, allelism and survival in non-small cell lung cancer

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12 December 2020

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

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12 December 2020

p53 and human cancer: the first ten thousand mutations.

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12 December 2020

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.

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12 December 2020

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

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12 December 2020

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

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12 December 2020

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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12 December 2020

Loss of heterozygosity is related to p53 mutations and smoking in lung cancer

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12 December 2020

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

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12 December 2020

p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

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12 December 2020

Polymorphisms in the p53 pathway.

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12 December 2020

Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

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12 December 2020

Identifiers

DOI

10.1038/SJ.ONC.1210932

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813802&resulttype=core&format=json

Dimensions Publication ID

12 May 2020

0 references

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813802&resulttype=core&format=json

12 May 2020

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