(Q40075798)

English

JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism

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scholarly article

1 reference

Europe PubMed Central

17 September 2017

JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism (English)

1 reference

Europe PubMed Central

17 September 2017

renal cell carcinoma

1 reference

based on heuristic

inferred from title

neoplastic invasiveness

1 reference

based on heuristic

inferred from title

author name string

Karen L Wu

1

1 reference

Europe PubMed Central

17 September 2017

Hui Miao

2

1 reference

Europe PubMed Central

17 September 2017

Shenaz Khan

3

1 reference

Europe PubMed Central

17 September 2017

publication date

26 September 2007

1 reference

Europe PubMed Central

17 September 2017

American Journal of Physiology - Renal Physiology

1 reference

Europe PubMed Central

17 September 2017

293

1 reference

Europe PubMed Central

17 September 2017

6

1 reference

Europe PubMed Central

17 September 2017

F1836-46

1 reference

Europe PubMed Central

17 September 2017

A road map for those who don't know JAK-STAT

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Stat proteins and oncogenesis

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Pim serine/threonine kinases regulate the stability of Socs-1 protein

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

SOCS proteins, regulators of intracellular signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Regulation of cytokine signaling by SOCS family molecules

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Negative regulators of cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Transforming growth factor alpha and mouse models of human breast cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Molecular basis of the VHL hereditary cancer syndrome

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

A gain-of-function mutation of JAK2 in myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Abl oncogene bypasses normal regulation of Jak/STAT activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

von Hippel-Lindau disease

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Jak kinase activity is required for lymphoma invasion and metastasis

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

HIF hydroxylation and the mammalian oxygen-sensing pathway

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Targeting of the VHL-Hypoxia-Inducible Factor-Hypoxia-Induced Gene Pathway for Renal Cell Carcinoma Therapy

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Jak family of kinases in cancer

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+ exchanger

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00096.2007

21 January 2018

Identifiers

10.1152/AJPRENAL.00096.2007

1 reference

Europe PubMed Central

17 September 2017

1 reference

Europe PubMed Central

17 September 2017

ResearchGate publication ID

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