(Q40108919)

17 September 2017

title

Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. (English)

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17 September 2017

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ChEBI release 2020-05-28

Beth A Carter

1

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17 September 2017

Olga A Taylor

2

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17 September 2017

Daniel R Prendergast

3

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17 September 2017

Tracy L Zimmerman

4

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17 September 2017

Richard Von Furstenberg

5

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17 September 2017

David D Moore

6

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17 September 2017

Saul J Karpen

7

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17 September 2017

language of work or name

English

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publication date

1 September 2007

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17 September 2017

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17 September 2017

volume

62

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17 September 2017

issue

3

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17 September 2017

page(s)

301-306

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https://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181256492

17 September 2017

exact match

0 references

cites work

Liver complications of pediatric parenteral nutrition--epidemiology

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Parenteral nutrition-associated cholestasis

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Parenteral nutrition-associated liver complications in children

21 January 2018

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Phytosterols in human nutrition

21 January 2018

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

BAPS prize lecture: New insight into mechanisms of parenteral nutrition-associated cholestasis: role of plant sterols. British Association of Paediatric Surgeons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Nuclear receptor regulation of hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids

21 January 2018

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

21 January 2018

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High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study

21 January 2018

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

21 January 2018

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

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Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children

21 January 2018

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Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters

21 January 2018

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Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine

21 January 2018

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

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Liver transplantation in a patient with sitosterolemia and cirrhosis.

21 January 2018

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Developmental pharmacology--drug disposition, action, and therapy in infants and children

21 January 2018

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Developmental expression of canalicular transporter genes in human liver

21 January 2018

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Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation

21 January 2018

1 reference

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Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260.

21 January 2018

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https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11

21 January 2018

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Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain

21 January 2018

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2FPDR.0B013E3181256492

10.1203/PDR.0B013E3181256492

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

17 September 2017

1027393865

0 references

1 reference