(Q40137988)

English

Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra

scientific article published on May 2007

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Europe PubMed Central

PubMed publication ID

17 September 2017

Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

substantia nigra

1 reference

based on heuristic

inferred from title

multiple endocrine neoplasia

1 reference

based on heuristic

inferred from title

Mikko Airavaara

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

3

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Petteri Piepponen

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

author name string

Jelena Mijatovic

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Petri Auvinen

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Atso Raasmaja

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Frank Costantini

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Liisa Ahtee

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Mart Saarma

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

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publication date

1 May 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Journal of Neuroscience

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

27

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

18

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

4799-4809

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RET proto-oncogene in the development of human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal sprouting following lesions of the rat substantia nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of dopamine receptors in regulating the size of axonal arbors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GDNF/RET signaling pathway and human diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel functions and signalling pathways for GDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor (GDNF) is required for differentiation of pontine noradrenergic neurons and patterning of central respiratory output

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In heterozygous GDNF knockout mice the response of striatal dopaminergic system to acute morphine is altered

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ret transforming gene encodes a fusion protein homologous to tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3,4-Dihydroxyphenylacetic acid and 4-hydroxy-3-methoxyphenylacetic acid in the mouse striatum: a reflection of intra- and extra-neuronal metabolism of dopamine?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term induction of tyrosine hydroxylase expression: compensatory response to partial degeneration of the dopaminergic nigrostriatal system in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the c-ret proto-oncogene during mouse embryogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional recovery in parkinsonian monkeys treated with GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF signalling through the Ret receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in enteric innervation and kidney development in mice lacking GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal and neuronal abnormalities in mice lacking GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a multicomponent receptor for GDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pre- and postnatal development of dopaminergic neuron numbers in the male and female mouse midbrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranigral or intrastriatal injections of GDNF: effects on monoamine levels and behavior in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The time course of developmental cell death in phenotypically defined dopaminergic neurons of the substantia nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of the ret- mutation on the normal development of the central and parasympathetic nervous systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presynaptic recording of quanta from midbrain dopamine neurons and modulation of the quantal size.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of GDNF family receptor components during development: implications in the mechanisms of interaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17475787

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5647-06.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672089&resulttype=core&format=json

16 May 2020

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