(Q34360698)

1 August 2017

1 reference

title

The GDNF/RET signaling pathway and human diseases (English)

1 reference

1 August 2017

Takahashi M

1

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1 August 2017

1 December 2001

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Cytokine and Growth Factor Reviews

1 August 2017

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1 August 2017

12

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1 August 2017

361-373

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1 August 2017

4

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Activation of a novel human transforming gene, ret, by DNA rearrangement

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

ret transforming gene encodes a fusion protein homologous to tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mutations of the RET proto-oncogene in Hirschsprung's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

The RET proto-oncogene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Low rate of ret proto-oncogene activation (PTC/retTPC) in papillary thyroid carcinomas from Saudi Arabia.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

High Prevalence of RET/PTC Rearrangements in Ukrainian and Belarussian Post-Chernobyl Thyroid Papillary Carcinomas: A Strong Correlation between RET/PTC3 and the Solid-Follicular Variant

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Gene rearrangement and Chernobyl related thyroid cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Preferential induction of RET/PTC1 rearrangement by X-ray irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Persephin, a novel neurotrophic factor related to GDNF and neurturin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GDNF signalling through the Ret receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Characterization of a multicomponent receptor for GDNF.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Calcium-dependent Ret activation by GDNF and neurturin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

1 reference

7 January 2021

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFRalpha-4, a new GDNF family receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Defects in enteric innervation and kidney development in mice lacking GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Renal and neuronal abnormalities in mice lacking GDNF

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Identification of Shc docking site on Ret tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Grb2 binding to the different isoforms of Ret tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Signal transduction by the receptor tyrosine kinase Ret.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

RET proto-oncogene in the development of human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Duplication of 9 base pairs in the critical cysteine-rich domain of the RET proto-oncogene causes multiple endocrine neoplasia type 2A

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Two germline missense mutations at codons 804 and 806 of the RET proto-oncogene in the same allele in a patient with multiple endocrine neoplasia type 2B without codon 918 mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Ganglioneuromas and renal anomalies are induced by activated RETMEN2B in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Multiple endocrine neoplasia type 2B mutation in human RET oncogene induces medullary thyroid carcinoma in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Loss of function effect of RET mutations causing Hirschsprung disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

A mutation in the RET proto-oncogene in Hirschsprung's disease affects the tyrosine kinase activity associated with multiple endocrine neoplasia type 2A and 2B

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Functional analysis of RET with Hirschsprung mutations affecting its kinase domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2801%2900012-0

7 January 2021

10.1016/S1359-6101(01)00012-0

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11544105