(Q40141648)

English

Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2.

scientific article published on May 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

1 reference

based on heuristic

inferred from title

pancreatic cancer

1 reference

based on heuristic

inferred from title

object named as

Pilar Navarro

8

0 references

Francisco X Real

object named as

Francisco X Real

7

0 references

author name string

Elena Ortiz-Zapater

1

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Sandra Peiró

2

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Oriol Roda

3

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Josep M Corominas

4

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Susana Aguilar

5

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Coral Ampurdanés

6

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

language of work or name

0 references

publication date

1 May 2007

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

The American Journal of Pathology

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

170

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

1573-1584

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

Epidermal growth factor receptor targeting in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

A proteomic approach to the identification of new tPA receptors in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Tenascin C and annexin II expression in the process of pancreatic carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Epidermal growth factor receptor (EGFR) signaling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Proteomic profiling of pancreatic cancer for biomarker discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Tissue plasminogen activator is a potent activator of PDGF-CC

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

uPA and uPAR in fibrinolysis, immunity and pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

The sphingomyelin/ceramide pathway is involved in ERK1/2 phosphorylation, cell proliferation, and uPAR overexpression induced by tissue-type plasminogen activator.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Gefitinib ('Iressa', ZD1839), a selective epidermal growth factor receptor tyrosine kinase inhibitor, inhibits pancreatic cancer cell growth, invasion, and colony formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

A "catastrophic hypothesis" for pancreas cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

New insights into the tPA-annexin A2 interaction. Is annexin A2 CYS8 the sole requirement for this association?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

uPAR: a versatile signalling orchestrator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Focus on pancreas cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Pancreatic cancer genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc compl

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Annexin II: a mediator of the plasmin/plasminogen activator system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Integrating genetic approaches into the discovery of anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Prognostic role of urokinase-type plasminogen activator in human gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

The epidermal growth factor receptor in human pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

22 September 2017

Urokinase activates calcium-dependent potassium channels in U937 cells via calcium release from intracellular stores

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

Annexin II tetramer: structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

Gastrointestinal cancer studies in the human to nude mouse heterotransplant system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

The role of annexin II tetramer in the activation of plasminogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

Plasminogen activators play an essential role in extracellular-matrix invasion by lymphoblastic T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

25 September 2017

Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

15 June 2018

The plasminogen-plasminogen activator (PA) system in neuroblastoma: role of PA inhibitor-1 in metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

15 June 2018

The urokinase-type plasminogen activator system in cancer metastasis: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

15 June 2018

Urokinase receptor and colorectal cancer survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

15 June 2018

In vitro properties of human melanoma cells metastatic in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

15 June 2018

Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

Effect of tissue plasminogen activator on vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

Plasminogen activator-plasmin system potentiates the proliferation of hepatocytes in primary culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

Stimulation of tissue type plasminogen activator by leukaemic cell homogenates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1854952

20 August 2018

The secretion of plasminogen activators by human myeloid leukemic cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A white paper: the product of a pancreas cancer think tank

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator is required for the growth, invasion, and angiogenesis of pancreatic tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-type plasminogen activator is a potent mitogen for human aortic smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in vessel wall plasminogen activator activity and smooth muscle cell proliferation and activation after arterial injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasminogen activators in nude mice xenotransplanted with human tumorigenic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of tissue-type plasminogen activator, cathepsin H, and non-specific cross-reacting antigen from SK-PC-1 pancreas cancer cells using subtractive hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue plasminogen activator increases canine endothelial cell proliferation rate through a plasmin-independent, receptor-mediated mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological significance of epidermal growth factor and its receptor in human pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The plasminogen activator system in pancreas cancer: role of t-PA in the invasive potential in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Annexin II and bleeding in acute promyelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17456763

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2007.060850

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 September 2017

ResearchGate publication ID

0 references

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