(Q40150613)

English

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

scientific article published on 26 November 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell (English)

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

apoptotic process

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1 reference

based on heuristic

inferred from title

author name string

Defeng Tian

1

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Sonia G Das

2

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Jignesh M Doshi

3

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Jun Peng

4

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Jialing Lin

5

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Chengguo Xing

6

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

language of work or name

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publication date

26 November 2007

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

259

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

198-208

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

1 reference

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1 reference

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Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer

1 reference

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HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1.

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1 reference

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Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

1 reference

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The Bcl-2 family: roles in cell survival and oncogenesis.

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Apoptosis: biochemical aspects and clinical implications

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A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

1 reference

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

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22 September 2017

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

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Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1 reference

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The Bcl-2 protein family: arbiters of cell survival

1 reference

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1 reference

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Two CD95 (APO-1/Fas) signaling pathways

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.

1 reference

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Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

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The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

1 reference

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Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

1 reference

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The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

1 reference

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FADD is required for multiple signaling events downstream of the receptor Fas.

1 reference

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Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but

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Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/18037229

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inferred from PubMed ID database lookup

Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18037229

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inferred from PubMed ID database lookup

Identifiers

10.1016/J.CANLET.2007.10.012

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

ResearchGate publication ID

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