(Q44598665)

English

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

scientific article published on October 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

multiple myeloma

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

1 reference

10.1038/SJ.LEU.2403109

https://api.crossref.org/works/10.1038/SJ.LEU.2403109

15 March 2024

2

object named as

Y. Dai

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14513055

15 March 2024

author name string

Pei XY

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

X-Y Pei

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14513055

15 March 2024

S. Grant

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14513055

15 March 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14513055

15 March 2024

publication date

1 October 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

full work available at URL

https://www.nature.com/articles/2403109.pdf

Portable Document Format

1 reference

10.1038/SJ.LEU.2403109

https://api.crossref.org/works/10.1038/SJ.LEU.2403109

15 March 2024

https://www.nature.com/articles/2403109

1 reference

10.1038/SJ.LEU.2403109

https://api.crossref.org/works/10.1038/SJ.LEU.2403109

15 March 2024

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

2036-2045

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403109

0 references

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

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21 January 2018

Death and anti-death: tumour resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

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21 January 2018

Thalidomide treatment in multiple myeloma

1 reference

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21 January 2018

Arsenic trioxide in multiple myeloma: rationale and future directions

1 reference

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21 January 2018

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Proteasome inhibition: a novel approach to cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

1 reference

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21 January 2018

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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21 January 2018

p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

1 reference

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21 January 2018

Novel therapies targeting the myeloma cell and its bone marrow microenvironment

1 reference

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21 January 2018

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Role for mitochondrial oxidants as regulators of cellular metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

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21 January 2018

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

1 reference

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21 January 2018

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia

1 reference

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21 January 2018

Potentiation of dexamethasone-, paclitaxel-, and Ad-p53-induced apoptosis by Bcl-2 antisense oligodeoxynucleotides in drug-resistant multiple myeloma cells.

1 reference

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21 January 2018

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

21 January 2018

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

1 reference

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21 January 2018

Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

1 reference

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21 January 2018

Using technology to decrease xerostomia for head and neck cancer patients treated with radiation therapy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

7 January 2021

based on heuristic

inferred from DOI database lookup

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

7 January 2021

based on heuristic

inferred from DOI database lookup

High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403109

7 January 2021

based on heuristic

inferred from DOI database lookup

Genes & Development

3

15

2922

author name string

X Wang

publication date

2001

1 reference

10.1038/SJ.LEU.2403109

https://api.crossref.org/works/10.1038/SJ.LEU.2403109

15 March 2024

Identifiers

10.1038/SJ.LEU.2403109

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

ResearchGate publication ID

0 references

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