(Q40155070)

18 September 2017

title

Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein (English)

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18 September 2017

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10

Eliezer Masliah

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18 September 2017

Igor F Tsigelny

1

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18 September 2017

Pazit Bar-On

2

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18 September 2017

Yuriy Sharikov

3

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18 September 2017

Leslie Crews

4

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18 September 2017

Makoto Hashimoto

5

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18 September 2017

Mark A Miller

6

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18 September 2017

Steve H Keller

7

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18 September 2017

Oleksandr Platoshyn

8

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18 September 2017

Jason X-J Yuan

9

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18 September 2017

language of work or name

English

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publication date

1 April 2007

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18 September 2017

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18 September 2017

volume

274

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18 September 2017

issue

7

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18 September 2017

page(s)

1862-1877

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

18 September 2017

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alpha-Synuclein locus triplication causes Parkinson's disease

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NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

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More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases

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Alpha-synuclein in Lewy body disease and Alzheimer's disease

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Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

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Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

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Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

21 January 2018

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A broken alpha -helix in folded alpha -Synuclein

21 January 2018

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Structure and dynamics of micelle-bound human alpha-synuclein

21 January 2018

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Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles

21 January 2018

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

21 January 2018

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Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

21 January 2018

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Forcing nonamyloidogenic beta-synuclein to fibrillate

21 January 2018

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Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

21 January 2018

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

21 January 2018

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

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The aggregation and fibrillation of alpha-synuclein

21 January 2018

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Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

21 January 2018

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

21 January 2018

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Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

21 January 2018

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A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

21 January 2018

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The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

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Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

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Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

21 January 2018

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Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

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Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

21 January 2018

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Secondary structure and dynamics of micelle bound beta- and gamma-synuclein

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

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Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells

21 January 2018

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Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants

21 January 2018

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In silico study of amyloid beta-protein folding and oligomerization

21 January 2018

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Raman spectroscopic characterization of secondary structure in natively unfolded proteins: alpha-synuclein

21 January 2018

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Common mechanisms of amyloid oligomer pathogenesis in degenerative disease

21 January 2018

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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

21 January 2018

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ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures

21 January 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

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Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

21 January 2018

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Zn2+ interaction with Alzheimer amyloid beta protein calcium channels

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Conformation-dependent anti-amyloid oligomer antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Constant pressure and temperature molecular dynamics simulation of a fully hydrated liquid crystal phase dipalmitoylphosphatidylcholine bilayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Reversible multiple time scale molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Docking essential dynamics eigenstructures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.05733.X

Misfolding of the amyloid β-protein: A molecular dynamics study

21 January 2018

1 reference

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10.1111/J.1742-4658.2007.05733.X

21 January 2018

Identifiers

DOI

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bmz6dx6ejje4nezoj5ujuhsg4q

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Fatcat ID

release_bmz6dx6ejje4nezoj5ujuhsg4q

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Fatcat

https://api.fatcat.wiki/v0/release/bmz6dx6ejje4nezoj5ujuhsg4q

mapped directly with Wikidata item

30 July 2022

based on heuristic

https://api.fatcat.wiki/v0/release/bmz6dx6ejje4nezoj5ujuhsg4q

1 reference