(Q40165778)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17327227%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

title

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation (English)

1 reference

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26 December 2019

1 reference

5

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26 December 2019

author name string

Eyal Avraham

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17327227%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Ruth Rott

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17327227%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Esti Liani

3

1 reference

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26 December 2019

Raymonde Szargel

4

1 reference

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26 December 2019

language of work or name

English

0 references

publication date

27 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17327227%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

26 December 2019

published in

1 reference

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26 December 2019

volume

282

1 reference

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26 December 2019

page(s)

12842-12850

1 reference

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26 December 2019

issue

17

1 reference

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Molecular pathophysiology of Parkinson's disease

26 December 2019

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Nosology of Parkinson's disease: looking for the way out of a quagmire

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

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Co-association of parkin and alpha-synuclein

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Pael-R is accumulated in Lewy bodies of Parkinson's disease.

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

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The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

21 January 2018

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Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

21 January 2018

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

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Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

21 January 2018

1 reference

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Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

21 January 2018

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Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.

21 January 2018

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p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease.

21 January 2018

1 reference

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

21 January 2018

1 reference

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Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608243200

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

21 January 2018

1 reference

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A brain-specific activator of cyclin-dependent kinase 5.

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

21 January 2018

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

21 January 2018

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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

21 January 2018

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Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

21 January 2018

1 reference

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Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

21 January 2018

1 reference

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Parkin accumulation in aggresomes due to proteasome impairment

21 January 2018

1 reference

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

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Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

21 January 2018

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Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease

21 January 2018

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Cdk5 deregulation in the pathogenesis of Alzheimer's disease

21 January 2018

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

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14-3-3eta is a novel regulator of parkin ubiquitin ligase

21 January 2018

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

1 reference

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Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients

21 January 2018

1 reference

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Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease

21 January 2018

1 reference

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M608243200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17327227%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference